Trial reportThe journal of headache and pain2009
Interictal quantitative EEG in migraine: a blinded controlled study.
Trial report in The journal of headache and pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
High-density EEG Evaluation of Functional Connectivity Changes in Migraine Patients Receiving Advanced Preventive Therapies (Anti-CGRP mAbs)
The Role of Resting State Networks Connectivity in Cluster Headache: a HD-EEG Study
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- What does a migraine aura look like?-A systematic review.The journal of headache and pain · 2025Pooled it
- Resting-state electroencephalography and magnetoencephalography in migraine-a systematic review and meta-analysis.The journal of headache and pain · 2024Pooled it
- Electroencephalographic Patterns in Chronic Pain: A Systematic Review of the Literature.PloS one · 2016Pooled it
- Source-level α periodic power in visual and default mode networks predicts topiramate treatment response in migraine.The journal of headache and pain · 2026Article
- Heightened Sensitivity of the Hyperexcitable Occipital Cortex to Spreading Depression: Evidence for State-Dependent Mechanisms of Migraine Aura.Neurology international · 2026Article
- Impact of Psychiatric Comorbidity on Cognitive Performance and EEG Theta/Beta Ratio: A Preliminary Study.Brain sciences · 2025Article
- The Role of Insular Cortex and Prefrontal Cortex in the Pathogenesis of Fibromyalgia: Biochemical and Electrophysiological Rodent Study.Neurochemical research · 2025Article
- 3T MRI thalamic segmentation reveals no macrostructural changes in interictal episodic migraine without aura compared to healthy controls.The journal of headache and pain · 2025Article
- Electroencephalographic signatures of migraine in small prospective and large retrospective cohorts.Scientific reports · 2024Article
- Advances and challenges in neuroimaging-based pain biomarkers.Cell reports. Medicine · 2024Review
- Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance.Aging and disease · 2024Review
- Article
- Quantitative electroencephalography as a potential biomarker in migraine.Brain and behavior · 2023Article
- [Transcranial alternating current stimulation to modulate oscillations in pain disorders].Schmerz (Berlin, Germany) · 2023Review
- Application of EEG in migraine.Frontiers in human neuroscience · 2023Review
- Attenuated alpha oscillation and hyperresponsiveness reveals impaired perceptual learning in migraineurs.The journal of headache and pain · 2022Article
- Abnormalities in resting-state EEG microstates are a vulnerability marker of migraine.The journal of headache and pain · 2022Article
- Resting State Electrophysiological Cortical Activity: A Brain Signature Candidate for Patients with Migraine.Current pain and headache reports · 2022Review
- Electroencephalography Signatures for Conditioned Pain Modulation and Pain Perception in Nonspecific Chronic Low Back Pain-An Exploratory Study.Pain medicine (Malden, Mass.) · 2022Article
- Effectiveness of Transcranial Direct Current Stimulation and Monoclonal Antibodies Acting on the CGRP as a Combined Treatment for Migraine (TACTIC): Protocol for a Randomized, Double-Blind, Sham-Controlled Trial.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal electroencephalography (EEG) in migraineurs has been reported in several studies. However, few have evaluated EEG findings in migraineurs during a time period when neither the last attack nor the next attack may interact with the results. We, therefore, compared interictal EEG in migraineurs and headache-free subjects with a design controlled for interference by pre-ictal changes. Pre-ictal EEG findings in the painful cranial side during the next attack after registration were also investigated. Correlations between clinical variables and EEG are reported as well. Interictal EEGs from 33 migraineurs (6 with and 27 without aura) and 31 controls were compared. Absolute power, asymmetry and relative power were studied for delta, theta and alpha frequency bands in parieto-occipital, temporal and fronto-central areas. EEG variables were correlated to attack frequency, headache duration, attack duration, pain intensity, photo- and phonophobia. Compared with controls, migraineurs had increased relative theta power in all cortical regions and increased delta activity in the painful fronto-central region. Absolute power and asymmetry were similar among groups. In age-adjusted analyses, headache intensity correlated with increased delta activity. In this blinded controlled study, we found globally increased relative theta activity in migraineurs. A slight interictal brain dysfunction is probably present between attacks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.