ArticleJournal of biomedicine & biotechnology2009
The phytoestrogen quercetin impairs steroidogenesis and angiogenesis in swine granulosa cells in vitro.
Article in Journal of biomedicine & biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 76 citations in OpenAlex.
- Flavonoid Composition and Molecular Basis of the Potential Sexual-Enhancing Properties of aPharmaceuticals (Basel, Switzerland) · 2026Article
- Natural Modulators of Aquaporins in Cancer Therapy: Functional Mechanisms and Clinical Potential.Molecules (Basel, Switzerland) · 2026Review
- Fine Particulate Matter (PM) Effects on Swine Granulosa and Ovarian Endothelial Cells.Animals : an open access journal from MDPI · 2025Article
- Enhancing impact of dietary nano formulated quercetin on laying performance: egg quality, oxidative stability of stored eggs, intestinal immune and antioxidants related genes expression.BMC veterinary research · 2024Article
- Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway.Journal of animal science and biotechnology · 2024Article
- UCHL1 promotes the proliferation of porcine granulosa cells by stabilizing CCNB1.Journal of animal science and biotechnology · 2024Article
- Rooibos (Aspalathus linearis) and its constituent quercetin can suppress ovarian cell functions and their response to FSH.Physiological research · 2023Article
- Effects of the Myokine Irisin on Stromal Cells from Swine Adipose Tissue.Biomolecules · 2022Article
- Redox Status, Estrogen and Progesterone Production by Swine Granulosa Cells Are Impaired by Triclosan.Animals : an open access journal from MDPI · 2022Article
- Perfluorooctanoic Acid (PFOA) Induces Redox Status Disruption in Swine Granulosa Cells.Veterinary sciences · 2022Article
- Combination of Quercetin and Vitamin E Supplementation Promotes Yolk Precursor Synthesis and Follicle Development in Aging Breeder Hens via Liver-Blood-Ovary Signal Axis.Animals : an open access journal from MDPI · 2021Article
- Evaluation of Triclosan Effects on Cultured Swine Luteal Cells.Animals : an open access journal from MDPI · 2021Article
- Effects ofChinese medical journal · 2018Article
- The effects of Salvia officinalis L. on granulosa cells and in vitro maturation of oocytes in mice.International journal of reproductive biomedicine · 2017Article
- Structural changes in femoral bone microstructure of female rabbits after intramuscular administration of quercetin.Acta veterinaria Scandinavica · 2016Article
- Effect of Antioxidant Flavonoids (Quercetin and Taxifolin) on In vitro Maturation of Porcine Oocytes.Asian-Australasian journal of animal sciences · 2016Article
- Geroprotective and Radioprotective Activity of Quercetin, (-)-Epicatechin, and Ibuprofen inFrontiers in pharmacology · 2016Article
- Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: promising options for prevention and treatment of uterine fibroids?Molecular nutrition & food research · 2014Review
- Quercetin improves the in vitro development of porcine oocytes by decreasing reactive oxygen species levels.Journal of veterinary science · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental evidence documents that nutritional phytoestrogens may interact with reproductive functions but the exact mechanism of action is still controversial. Since quercetin is one of the main flavonoids in livestock nutrition, we evaluated its possible effects on cultured swine granulosa cell proliferation, steroidogenesis, and redox status. Moreover, since angiogenesis is essential for follicle development, the effect of the flavonoid on Vascular Endothelial Growth Factor output by granulosa cells was also taken into account. Our data evidence that quercetin does not affect granulosa cell growth while it inhibits progesterone production and modifies estradiol 17beta production in a dose-related manner. Additionally, the flavonoid interferes with the angiogenic process by inhibiting VEGF production as well as by altering redox status. Since steroidogenesis and angiogenesis are strictly involved in follicular development, these findings appear particularly relevant, pointing out a possible negative influence of quercetin on ovarian physiology. Therefore, the possible reproductive impact of the flavonoid should be carefully considered in animal nutrition.
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