ArticleCommunicative & integrative biology2009
Connexin 43 gap junction plaque endocytosis implies molecular remodelling of ZO-1 and c-Src partners.
Article in Communicative & integrative biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Connexins in Astrocyte Migration.Frontiers in pharmacology · 2019Review
- Connexin-43 K63-polyubiquitylation on lysines 264 and 303 regulates gap junction internalization.Journal of cell science · 2018Article
- Loss of Cx43-Mediated Functional Gap Junction Communication in Meningeal Fibroblasts Following Mouse Hepatitis Virus Infection.Molecular neurobiology · 2018Article
- TheOpen biology · 2017Article
- Decreased mRNA levels of cardiac Cx43 and ZO1 in sudden cardiac death related to coronary atherosclerosis: a pilot study.International journal of legal medicine · 2016Article
- Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization.Molecular biology of the cell · 2015Article
- Effects of high glucose-induced Cx43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells.Investigative ophthalmology & visual science · 2013Article
- In vivo and in vitro cardiac responses to beta-adrenergic stimulation in volume-overload heart failure.Journal of molecular and cellular cardiology · 2013Article
- Designer gap junctions that prevent cardiac arrhythmias.Trends in cardiovascular medicine · 2013Review
- Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner.Carcinogenesis · 2012Article
- The blood-testis barrier and its implications for male contraception.Pharmacological reviews · 2012Review
- Testicular connexin 43, a precocious molecular target for the effect of environmental toxicants on male fertility.Spermatogenesis · 2011Article
- Phosphatase-resistant gap junctions inhibit pathological remodeling and prevent arrhythmias.Circulation research · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gap junctions, through their constitutive proteins, connexins (Cx), are involved in several processes including regulation of cellular proliferation, tissue differentiation, homeostasis and neoplasic transformation. Internalization of the gap junction plaque to form annular gap junction is a dynamic process, which present similarities with endocytosis, and participates in the control of gap junction coupling. Cx43 exhibits dynamic trafficking that needs sequential implication of a large number of protein partners. We have recently shown that ZO-1 localized in both sides of the gap junction plaque was restricted to one side during internalization. The dissociation between ZO-1 and Cx43 particularly occurred on the face where c-Src specifically associated with Cx43 and was abnormally accelerated in response to a carcinogen. In this addendum we summarize and further discuss these results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.