ArticlePlant signaling & behavior2008
The role of AtNUDT7, a Nudix hydrolase, in the plant defense response.
Article in Plant signaling & behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Combining two high-density QTL maps with a reference genome to identify candidate genes for morphology, yield, and biotic resistance in faba bean (Frontiers in plant science · 2026Article
- Multi-Locus GWAS Mapping and Candidate Gene Analysis of Anticancer Peptide Lunasin in Soybean (Plants (Basel, Switzerland) · 2025Article
- Gaining insights into genomic regions associated withFrontiers in genetics · 2025Article
- Transcriptome Analysis of Potato Infected with the Necrotrophic PathogenPlants (Basel, Switzerland) · 2021Article
- Data-Independent-Acquisition-Based Proteomic Approach towards Understanding the Acclimation Strategy of Oleaginous MicroalgaACS omega · 2021Article
- A genome-wide association study identifiesVirus evolution · 2021Article
- Genome-wide analysis of small RNAs from Odontoglossum ringspot virus and Cymbidium mosaic virus synergistically infecting Phalaenopsis.Molecular plant pathology · 2020Article
- Genome-wide association study identified candidate genes controlling continuous storage root formation and bulking in hexaploid sweetpotato.BMC plant biology · 2020Article
- Fusarium oxysporum f. sp. phaseoli genetic variability assessed by new developed microsatellites.Genetics and molecular biology · 2020Article
- Identification of genomic regions associated with shoot fly resistance in maize and their syntenic relationships in the sorghum genome.PloS one · 2020Article
- Zucchini Plants Alter Gene Expression and Emission of (Frontiers in plant science · 2020Article
- The genetic architecture of amylose biosynthesis in maize kernel.Plant biotechnology journal · 2018Article
- The evolution of function within the Nudix homology clan.Proteins · 2017Article
- NAD Acts as an Integral Regulator of Multiple Defense Layers.Plant physiology · 2016Article
- Nudix Effectors: A Common Weapon in the Arsenal of Plant Pathogens.PLoS pathogens · 2016Review
- The Activation of Phytophthora Effector Avr3b by Plant Cyclophilin is Required for the Nudix Hydrolase Activity of Avr3b.PLoS pathogens · 2015Article
- Redox regulation in plant immune function.Antioxidants & redox signaling · 2014Review
- Article
- NAD: not just a pawn on the board of plant-pathogen interactions.Plant signaling & behavior · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nudix hydrolases constitute a large family of proteins that hydrolyze nucleoside diphosphate derivatives. Some Nudix hydrolases act as 'housecleaning' enzymes whereas others may function to sense and modulate the levels of their substrates to maintain physiological homeostasis. The Arabidopsis genome encodes 32 Nudix proteins (AtNUDTs). However, their physiological substrates and biological functions are little known. AtNUDT7 has been identified as a negative regulator of the defense response and its loss-of-function mutation leads to enhanced disease resistance and makes the plants hyper-responsive to inciting agents including pathogenic as well as nonpathogenic micro-organisms. Based on in vitro enzymatic characterization, it was speculated that ADP-ribose (ADPR) and/or NADH may be biologically significant substrates of AtNUDT7. However, our result from determination of the levels of ADPR and NAD(H) in the mutant and wild-type plants indicates neither of these nucleotide analogs likely is its physiological substrates. The Atnudt7 mutant does have a higher ratio of GSSG/GSH than wild-type plants. This alteration in redox homeostasis may prime the mutant plants for excessive cellular stimulation when being provoked by biotic stresses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.