ArticlePlant signaling & behavior2009
Plant TPX2 and related proteins.
Article in Plant signaling & behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Enhanced expression of theGM crops & food · 2026Article
- Article
- The unconventional TPX2 family protein TPXL3 regulates α Aurora kinase function in spindle morphogenesis in Arabidopsis.The Plant cell · 2025Article
- CRISPR/Cas9-based gene activation and base editing inHorticulture research · 2023Article
- Spindle motility skews division site determination during asymmetric cell division in Physcomitrella.Nature communications · 2022Article
- A guide to plant TPX2-like and WAVE-DAMPENED2-like proteins.Journal of experimental botany · 2021Article
- Functional Divergence of Microtubule-Associated TPX2 Family Members inInternational journal of molecular sciences · 2020Article
- Article
- Identification ofGenes · 2019Article
- TPX2-LIKE PROTEIN3 Is the Primary Activator of α-Aurora Kinases and Is Essential for Embryogenesis.Plant physiology · 2019Article
- Genome-wide analysis of the TPX2 family proteins in Eucalyptus grandis.BMC genomics · 2016Article
- The C-terminal domain of TPX2 is made of alpha-helical tandem repeats.BMC structural biology · 2016Article
- Overexpressed TPX2 causes ectopic formation of microtubular arrays in the nuclei of acentrosomal plant cells.Journal of experimental botany · 2013Article
- Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At the onset of mitosis, microtubules form a bipolar spindle around the prophase nucleus. TPX2 is phosphorylated during mitosis and acts as a spindle assembly factor that nucleates microtubules in the close vicinity of chromosomes, independent of the centrosomes. Furthermore, it activates the kinase Aurora A and targets the Xenopus kinesin-like protein 2 to spindle poles. We have characterized the plant orthologue of TPX2 that possesses all identified functional domains of its animal counterpart. Moreover, we have demonstrated that it is exported before nuclear envelope breakdown and that its activity around the nuclear envelope is essential for prospindle assembly. Here, we compare the sequences of several characterized TPX2 domains, allowing us to define TPX2. We propose that true TPX2 orthologues share simultaneously all these conserved domains and that other proteins possessing only some of these functional blocks may be considered as TPX2-related proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.