ArticleThe Journal of cell biology2009
A requirement for epsin in mitotic membrane and spindle organization.
Article in The Journal of cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Endoplasmic reticulum membranes are continuously required to maintain mitotic spindle size and forces.Life science alliance · 2023Article
- Clathrin Is Important for Virulence Factors Delivery in the Necrotrophic FungusFrontiers in plant science · 2021Article
- Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations.Cells · 2019Review
- BOARD INVITED REVIEW: Post-transfer consequences of in vitro-produced embryos in cattle.Journal of animal science · 2019Review
- Epsins Regulate Mouse Embryonic Stem Cell Exit from Pluripotency and Neural Commitment by Controlling Notch Activation.Stem cells international · 2019Article
- Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation.PloS one · 2018Article
- Epsin2 promotes polarity establishment and meiotic division through activating Cdc42 in mouse oocyte.Oncotarget · 2016Article
- An organelle-exclusion envelope assists mitosis and underlies distinct molecular crowding in the spindle region.The Journal of cell biology · 2015Article
- Commentary: Rab GTPase: A New Mitotic Delivery Service.Frontiers in cell and developmental biology · 2015Article
- Rab5a is required for spindle length control and kinetochore-microtubule attachment during meiosis in oocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Article
- Borg5 is required for angiogenesis by regulating persistent directional migration of the cardiac microvascular endothelial cells.Molecular biology of the cell · 2014Article
- Protein adaptation: mitotic functions for membrane trafficking proteins.Nature reviews. Molecular cell biology · 2013Review
- Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells.Molecular cancer · 2013Article
- Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation.PloS one · 2013Article
- Article
- Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.The Journal of cell biology · 2012Article
- Altering membrane topology with Sar1 does not impair spindle assembly in Xenopus egg extracts.Cytoskeleton (Hoboken, N.J.) · 2012Article
- The epsin protein family: coordinators of endocytosis and signaling.Biomolecular concepts · 2012Article
- Clathrin is required for postmitotic Golgi reassembly.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Eukaryotic cells possess a sophisticated membrane system to facilitate diverse functions. Whereas much is known about the nature of membrane systems in interphase, the organization and function of the mitotic membrane system are less well understood. In this study, we show that epsin, an endocytic adapter protein, regulates mitotic membrane morphology and spindle integrity in HeLa cells. Using epsin that harbors point mutations in the epsin NH2-terminal homology domain and spindle assembly assays in Xenopus laevis egg extracts, we show that epsin-induced membrane curvature is required for proper spindle morphogenesis, independent of its function in endocytosis during interphase. Although several other membrane-interacting proteins, including clathrin, AP2, autosomal recessive hypercholesterolemia, and GRASP65, are implicated in the regulation of mitosis, whether they participate through regulation of membrane organization is unclear. Our study of epsin provides evidence that mitotic membrane organization influences spindle integrity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.