ArticleGenetics2009
Imprinting of the Y chromosome influences dosage compensation in roX1 roX2 Drosophila melanogaster.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Fitness consequences of sex chromosome aneuploidy in Drosophila melanogaster.PLoS genetics · 2025Article
- Genetic control of a sex-specific piRNA program.Current biology : CB · 2023Article
- Sex-limited chromosomes and non-reproductive traits.BMC biology · 2022Review
- Article
- RNA-on-X 1 and 2 in Drosophila melanogaster fulfill separate functions in dosage compensation.PLoS genetics · 2018Article
- Article
- Sex-specific adaptation and genomic responses to Y chromosome presence in female reproductive and neural tissues.Proceedings. Biological sciences · 2017Article
- Satellite Repeats Identify X Chromatin for Dosage Compensation in Drosophila melanogaster Males.Current biology : CB · 2017Article
- Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.Nature structural & molecular biology · 2016Article
- Non-coding roX RNAs prevent the binding of the MSL-complex to heterochromatic regions.PLoS genetics · 2014Article
- Endogenously imprinted genes in Drosophila melanogaster.Molecular genetics and genomics : MGG · 2014Article
- Genome-wide gene expression effects of sex chromosome imprinting in Drosophila.G3 (Bethesda, Md.) · 2014Article
- How do y-chromosomes modulate genome-wide epigenetic States: genome folding, chromatin sinks, and gene expression.Journal of genomics · 2014Review
- Epigenetics and sex-specific fitness: an experimental test using male-limited evolution in Drosophila melanogaster.PloS one · 2013Article
- Genomic imprinting absent in Drosophila melanogaster adult females.Cell reports · 2012Article
- Article
- X- and Y-chromosome linked paternal effects on a life-history trait.Biology letters · 2012Article
- Epigenetic mechanisms of genomic imprinting: common themes in the regulation of imprinted regions in mammals, plants, and insects.Genetics research international · 2012Article
- msl2 mRNA is bound by free nuclear MSL complex in Drosophila melanogaster.Nucleic acids research · 2011Article
- Empirical evidence for son-killing X chromosomes and the operation of SA-zygotic drive.PloS one · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Drosophila melanogaster males have a well-characterized regulatory system that increases X-linked gene expression. This essential process restores the balance between X-linked and autosomal gene products in males. A complex composed of the male-specific lethal (MSL) proteins and RNA is recruited to the body of transcribed X-linked genes where it modifies chromatin to increase expression. The RNA components of this complex, roX1 and roX2 (RNA on the X1, RNA on the X2), are functionally redundant. Males mutated for both roX genes have dramatically reduced survival. We show that reversal of sex chromosome inheritance suppresses lethality in roX1 roX2 males. Genetic tests indicate that the effect on male survival depends upon the presence and source of the Y chromosome, revealing a germ line imprint that influences dosage compensation. Conventional paternal transmission of the Y chromosome enhances roX1 roX2 lethality, while maternal transmission of the Y chromosome suppresses lethality. roX1 roX2 males with both maternal and paternal Y chromosomes have very low survival, indicating dominance of the paternal imprint. In an otherwise wild-type male, the Y chromosome does not appreciably affect dosage compensation. The influence of the Y chromosome, clearly apparent in roX1 roX2 mutants, thus requires a sensitized genetic background. We believe that the Y chromosome is likely to act through modulation of a process that is defective in roX1 roX2 mutants: X chromosome recognition or chromatin modification by the MSL complex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.