ArticleThe Journal of physiology2009
Multifunctional rapidly adapting mechanosensitive enteric neurons (RAMEN) in the myenteric plexus of the guinea pig ileum.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Esophageal peristalsis in health and disease: mechanistic insights.Physiological reviews · 2026Review
- Decoding Gastric Reflexes: The Role of Mechanosensitive Enteric Neurons in Stomach Motility.Neurogastroenterology and motility · 2025Review
- Identified neurons B4/B5 function as sensory neurons, motor neurons, and interneurons inJournal of neurophysiology · 2025Article
- Activation of mechanoreceptor Piezo1 inhibits enteric neuronal growth and migrationFrontiers in molecular neuroscience · 2024Article
- The influence of Nav1.9 channels on intestinal hyperpathia and dysmotility.Channels (Austin, Tex.) · 2023Review
- Calcium image analysis in the moving gut.Neurogastroenterology and motility · 2023Article
- The enteric nervous system.Physiological reviews · 2023Review
- Article
- Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract.International journal of molecular sciences · 2022Review
- Gut feelings: mechanosensing in the gastrointestinal tract.Nature reviews. Gastroenterology & hepatology · 2022Review
- Activation of ENS Circuits in Mouse Colon: Coordination in the Mouse Colonic Motor Complex as a Robust, Distributed Control System.Advances in experimental medicine and biology · 2022Review
- The role of mechanosensitive ion channels in the gastrointestinal tract.Frontiers in physiology · 2022Review
- Modification of Neurogenic Colonic Motor Behaviours by Chemogenetic Ablation of Calretinin Neurons.Frontiers in cellular neuroscience · 2022Article
- Structure, kinetic properties and biological function of mechanosensitive Piezo channels.Cell & bioscience · 2021Review
- Characterization of putative interneurons in the myenteric plexus of human colon.Neurogastroenterology and motility · 2021Article
- scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3.Cellular and molecular gastroenterology and hepatology · 2021Article
- The identification of neuronal control pathways supplying effector tissues in the stomach.Cell and tissue research · 2020Review
- Submucosal enteric neurons of the cavine distal colon are sensitive to hypoosmolar stimuli.The Journal of physiology · 2020Article
- Functional circuits and signal processing in the enteric nervous system.Cellular and molecular life sciences : CMLS · 2020Review
- Compression and stretch sensitive submucosal neurons of the porcine and human colon.Scientific reports · 2020Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
An important feature of the enteric nervous system (ENS) is its capability to respond to mechanical stimulation which, as currently suggested for the guinea-pig ileum, is encoded by specialized intrinsic primary afferent neurons (IPANs). We used von Frey hairs or intraganglionic volume injections to mimic ganglion deformation as observed in freely contracting preparations. Using fast voltage-sensitive dye imaging we identified rapidly adapting mechanosensitive enteric neurons (RAMEN, 25% of all neurons) in the myenteric plexus of the guinea pig ileum. RAMEN responded with phasic spike discharge to dynamic changes during ganglion deformation. This response was reproducible and increased with increasing forces. Deformation-evoked spike discharge was not changed by synaptic blockade with hexamethonium, omega-conotoxin or low Ca(2+)/high Mg(2+), defunctionalization of extrinsic afferents with capsaicin or muscle paralysis with nifedipine, suggesting direct activation of RAMEN. All RAMEN received hexamethonium-sensitive fast EPSPs, which were blocked by omega-conotoxin and low Ca(2+)/high Mg(2+). Seventy-two per cent of RAMEN were cholinergic, 22% nitrergic, and 44% were calbindin and NeuN negative, markers used to identify IPANs. Mechanosensitivity was observed in 31% and 47% of retrogradely traced interneurons and motor neurons, respectively. RAMEN belong to a new population of mechanosensitive neurons which differ from IPANs. We provided evidence for multifunctionality of RAMEN which may fulfil sensory, integrative and motor functions. In light of previously identified mechanosensitive neuron populations, mechanosensitivity appears to be a property of many more enteric neurons than generally assumed. The findings call for a revision of current concepts on sensory transmission within the ENS.
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