ArticleThe Journal of physiology2009
Defining the excitatory neurons that drive the locomotor rhythm in a simple vertebrate: insights into the origin of reticulospinal control.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 82 citations in OpenAlex.
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- Mechanisms Underlying the Recruitment of Inhibitory Interneurons in Fictive Swimming in DevelopingThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- An early midbrain sensorimotor pathway is involved in the timely initiation and direction of swimming in the hatchlingFrontiers in neural circuits · 2022Article
- From decision to action: Detailed modelling of frog tadpoles reveals neuronal mechanisms of decision-making and reproduces unpredictable swimming movements in response to sensory signals.PLoS computational biology · 2021Article
- The early development and physiology ofJournal of neurophysiology · 2021Article
- Command or Obey? Homologous Neurons Differ in Hierarchical Position for the Generation of Homologous Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The decision to move: response times, neuronal circuits and sensory memory in a simple vertebrate.Proceedings. Biological sciences · 2019Review
- Hindbrain V2a Neurons Pattern Rhythmic Activity of Motor Neurons in a Reticulospinal Coculture.Frontiers in neuroscience · 2019Article
- Stimulation of Single, Possible CHX10 Hindbrain Neurons Turns Swimming On and Off in YoungFrontiers in cellular neuroscience · 2019Article
- A simple decision to move in response to touch reveals basic sensory memory and mechanisms for variable response times.The Journal of physiology · 2018Article
- Bifurcations of Limit Cycles in a Reduced Model of the Xenopus Tadpole Central Pattern Generator.Journal of mathematical neuroscience · 2018Article
- Principles Governing Locomotion in Vertebrates: Lessons From Zebrafish.Frontiers in neural circuits · 2018Review
- Zebrafish transgenic constructs label specific neurons in Xenopus laevis spinal cord and identify frog V0v spinal neurons.Developmental neurobiology · 2017Article
- The modulation of two motor behaviors by persistent sodium currents inJournal of neurophysiology · 2017Article
- Article
- The central pattern generator underlying swimming in Dendronotus iris: a simple half-center network oscillator with a twist.Journal of neurophysiology · 2016Article
- Modelling Feedback Excitation, Pacemaker Properties and Sensory Switching of Electrically Coupled Brainstem Neurons Controlling Rhythmic Activity.PLoS computational biology · 2016Article
- Imaging fictive locomotor patterns in larval Drosophila.Journal of neurophysiology · 2015Article
- Choosing sides: making decisions in an escape response.The Journal of physiology · 2015Article
- Sensory initiation of a co-ordinated motor response: synaptic excitation underlying simple decision-making.The Journal of physiology · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Important questions remain about the origin of the excitation that drives locomotion in vertebrates and the roles played by reticulospinal neurons. In young Xenopus tadpoles, paired whole-cell recordings reveal reticulospinal neurons that directly excite swimming circuit neurons in the brainstem and spinal cord. They form part of a column of neurons (dINs) with ipsilateral descending projections which fire reliably and rhythmically in time with swimming. We ask if, at this early stage of development, these reticulospinal neurons are themselves the primary source of rhythmic drive to spinal cord neurons on each cycle of swimming. Loose-patch recordings in the hindbrain and spinal cord from neurons active during fictive swimming distinguished dINs from other neurons by spike shape. These recordings showed that reticulospinal dINs in the caudal hindbrain (rhombomeres 7-8) fire significantly earlier on each swimming cycle than other, ipsilateral, swimming circuit neurons. Whole-cell recordings showed that fast EPSCs typically precede, and probably drive, spikes in most swimming circuit neurons. However, the earliest-firing reticulospinal dINs spike too soon to be driven by underlying fast EPSCs. We propose that rebound following reciprocal inhibition can contribute to early reticulospinal dIN firing during swimming and show rebound firing in dINs following evoked, reciprocal inhibitory PSPs. Our results define reticulospinal neurons that are the source of the primary, descending, rhythmic excitation that drives spinal cord neurons to fire during swimming. These neurons are an integral part of the rhythm generating circuitry. We discuss the origin of these reticulospinal neurons as specialised members of a longitudinally distributed population of excitatory interneurons extending from the brainstem into the spinal cord.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.