ArticleThe Journal of biological chemistry2009
Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development.The Journal of biological chemistry · 2013Trial
- S-SCAM is essential for synapse formation.Frontiers in cellular neuroscience · 2023Article
- SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Adaptor protein APPL1 links neuronal activity to chromatin remodeling in cultured hippocampal neurons.Journal of molecular cell biology · 2021Article
- Nutrient limitation affects presynaptic structures through dissociable Bassoon autophagic degradation and impaired vesicle release.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning.Nature neuroscience · 2017Article
- The Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic SPAR Levels and the Maturation of Dendritic Spines in Hippocampal Neurons.Frontiers in synaptic neuroscience · 2016Article
- Ehlers-Danlos Syndrome, Hypermobility Type, Is Linked to Chromosome 8p22-8p21.1 in an Extended Belgian Family.Disease markers · 2015Article
- Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID.Molecular autism · 2015Article
- mir-300 promotes self-renewal and inhibits the differentiation of glioma stem-like cells.Journal of molecular neuroscience : MN · 2014Article
- Cognitive flexibility and long-term depression (LTD) are impaired following β-catenin stabilization in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Wnts are expressed in the spinal cord of adult mice and are differentially induced after injury.Journal of neurotrauma · 2014Article
- The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons.Neural development · 2013Article
- Wnt signaling in the pathogenesis of human HIV-associated pain syndromes.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Article
- Physiological role of β-catenin/TCF signaling in neurons of the adult brain.Neurochemical research · 2013Review
- Novel β-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability.BMC genomics · 2012Article
- Regulation of Wnt signaling by nociceptive input in animal models.Molecular pain · 2012Article
- Article
- IκB kinase/nuclear factor κB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory formation in the brain is thought to be depending upon long lasting plastic changes of synaptic contacts that require alterations on the transcriptional level. Here, we characterize LAPSER1, a putative cytokinetic tumor suppressor that binds directly to ProSAP2/Shank3 and the synaptic Rap-Gap protein SPAR1 as a novel postsynaptic density component. Postsynaptic LAPSER1 is in complex with all important members of the canonical Wnt pathway including beta-catenin. Upon N-methyl-D-aspartate receptor-dependent activation, LAPSER1 and beta-catenin comigrate from the postsynaptic density to the nucleus and induce the transcription and translation of known beta-catenin target genes, including Tcfe2a and c-Myc. The nuclear export and cytoplasmic redistribution of beta-catenin is tightly regulated by LAPSER1. We postulate a postsynaptic cross-talk between N-methyl-D-aspartate receptors and a LAPSER1-beta-catenin complex that results in a self-regulated, synaptic activity-dependent expression of beta-catenin target genes. This calls for a novel role of Tcfe2a and c-Myc in plastic changes of neural tissue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.