Trial reportThorax2010
Short-term comparative study of high frequency chest wall oscillation and European airway clearance techniques in patients with cystic fibrosis.
Trial report in Thorax, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 30 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-Invasive Ventilation (NIV) For Positive Pressure Support. A Randomised Cross-Over Trial To Evaluate The Short-Term Effects of NIV As An Adjunct To Airway Clearance Techniques in Adults With Cystic Fibrosis.
Improving Outcome Measures For Physiotherapy Trials of Airway Clearance in Adults With Cystic Fibrosis
Who cites it
30 citing papers in PubMed, 10 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Airway clearance techniques compared to no airway clearance techniques for cystic fibrosis.The Cochrane database of systematic reviews · 2023Pooled it
- Active cycle of breathing technique for cystic fibrosis.The Cochrane database of systematic reviews · 2023Pooled it
- Autogenic drainage for airway clearance in cystic fibrosis.The Cochrane database of systematic reviews · 2021Pooled it
- Oscillating devices for airway clearance in people with cystic fibrosis.The Cochrane database of systematic reviews · 2020Pooled it
- Airway clearance techniques for cystic fibrosis: an overview of Cochrane systematic reviews.The Cochrane database of systematic reviews · 2019Pooled it
- Autogenic drainage for airway clearance in cystic fibrosis.The Cochrane database of systematic reviews · 2017Pooled it
- Oscillating devices for airway clearance in people with cystic fibrosis.The Cochrane database of systematic reviews · 2017Pooled it
- Active cycle of breathing technique for cystic fibrosis.The Cochrane database of systematic reviews · 2016Pooled it
- Chest physiotherapy compared to no chest physiotherapy for cystic fibrosis.The Cochrane database of systematic reviews · 2015Pooled it
- Effectiveness of positive expiratory pressure on patients over 16 years of age with cystic fibrosis: systematic review and meta-analysis.Therapeutic advances in respiratory diseasePooled it
- Adjunctive Short-Wave Diathermy to High-Frequency Chest Wall Oscillation for Acute Exacerbation of COPD: A Randomized Controlled Trial.Canadian respiratory journal · 2026Trial
- The effectiveness of a mobile high-frequency chest wall oscillation (HFCWO) device for airway clearance.Pediatric pulmonology · 2020Trial
- Trial
- Randomised cross-over trial evaluating the short-term effects of non-invasive ventilation as an adjunct to airway clearance techniques in adults with cystic fibrosis.BMJ open respiratory research · 2019Trial
- Safety and effectiveness of the high-frequency chest wall oscillation vs intrapulmonary percussive ventilation in patients with severe COPD.International journal of chronic obstructive pulmonary disease · 2018Trial
- Effectiveness of treatment with high-frequency chest wall oscillation in patients with bronchiectasis.BMC pulmonary medicine · 2013Trial
- Acoustic therapy for allergic rhinitis and chronic rhinosinusitis: modulating microbiome, immunity and well-being.Frontiers in allergy · 2025Review
- Nursing Process Related to the Nursing Focus "Airway Clearance": A Scoping Review.Nursing reports (Pavia, Italy) · 2024Article
- Mucus hypersecretion in chronic obstructive pulmonary disease: From molecular mechanisms to treatment.Journal of translational internal medicine · 2023Article
- Effectiveness of Autogenic Drainage in Improving Pulmonary Function in Patients with Cystic Fibrosis.International journal of environmental research and public health · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh frequency chest wall oscillation (HFCWO) is standard treatment for airway clearance in the USA and has recently been introduced in the UK and Europe. There is little published research comparing HFCWO with airway clearance techniques (ACTs) frequently used in the UK and Europe. The aim of this study was to compare the short-term effects of HFCWO with usual ACTs in patients with cystic fibrosis hospitalised with an infective pulmonary exacerbation.
methodsA 4-day randomised crossover design was used. Patients received either HFCWO on days 1 and 3 and usual ACTs on days 2 and 4 or vice versa. Wet weight of sputum, spirometry and oxygen saturation were measured. Perceived efficacy, comfort, incidence of urinary leakage and preference were assessed. Data were analysed by mixed model analysis.
results29 patients (72% male) of mean (SD) age 29.4 (8.4) years and mean (SD) forced expiratory volume in 1 s (FEV(1)) percentage predicted (FEV(1)%) 38 (16.7) completed the study. Significantly more sputum was expectorated during a single treatment session and over a 24 h period (mean difference 4.4 g and 6.9 g, respectively) with usual ACTs than with HFCWO (p<0.001). No statistically significant change in FEV(1)% or oxygen saturation was observed after either HFCWO or usual ACTs compared with baseline. 17 patients (55%) expressed a preference for their usual ACT.
conclusionsDuring both a finite treatment period and over 24 h, less sputum was cleared using HFCWO than usual ACT. HFCWO does not appear to cause any adverse physiological effects and may influence adherence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.