Trial reportRespiratory research2009
Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients.
Trial report in Respiratory research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02823587 (Effects of Pulmonary Rehabilitation on Secretion Transport, Inflammation and Respiratory System Strength and Quality of Life in Patients With Bronchiectasis), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Pulmonary Rehabilitation on Secretion Transport, Inflammation and Respiratory System Strength and Quality of Life in Patients With Bronchiectasis
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inflammatory Biomarkers in Exhaled Breath Condensate: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Clinical, functional and inflammatory evaluation in asthmatic patients after a simple short-term educational program: a randomized trial.Scientific reports · 2021Trial
- Trial
- DASH for asthma: a pilot study of the DASH diet in not-well-controlled adult asthma.Contemporary clinical trials · 2013Trial
- Trial
- The Future of Hydrogen Peroxide as a Biomarker for Airway Inflammation.Journal of inflammation research · 2026Review
- Measurement of Human and Bovine Exhaled Breath Condensate pH Using Polyaniline-Modified Flexible Inkjet-Printed Nanocarbon Electrodes.ACS omega · 2024Article
- The Role of Exhaled Breath Condensate in Chronic Inflammatory and Neoplastic Diseases of the Respiratory Tract.International journal of molecular sciences · 2024Review
- Exhaled Breath Condensate-A Non-Invasive Approach for Diagnostic Methods in Asthma.Journal of clinical medicine · 2021Review
- A Review of Analytical Techniques and Their Application in Disease Diagnosis in Breathomics and Salivaomics Research.International journal of molecular sciences · 2016Review
- Article
- Exhaled Breath Condensate: Technical and Diagnostic Aspects.TheScientificWorldJournal · 2015Review
- Article
- Bronchoalveolar pH and inflammatory biomarkers in newly diagnosed IPF and GERD patients: a case-control study.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers.Clinics (Sao Paulo, Brazil) · 2013Article
- The degradation of airway tight junction protein under acidic conditions is probably mediated by transient receptor potential vanilloid 1 receptor.Bioscience reports · 2013Article
- A mobile instrumentation platform to distinguish airway disorders.Journal of breath research · 2013Article
- Exhaled breath condensate pH in patients with cystic fibrosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Comparison of two devices and two breathing patterns for exhaled breath condensate sampling.PloS one · 2011Article
- Isoprostanes-biomarkers of lipid peroxidation: their utility in evaluating oxidative stress and analysis.International journal of molecular sciences · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnalysis of exhaled breath condensate (EBC) is a non-invasive method for studying the acidity (pH) of airway secretions in patients with inflammatory lung diseases.
aimTo assess the reproducibility of EBC pH for two commercially available devices (portable RTube and non-portable ECoScreen) in healthy controls, patients with asthma or COPD, and subjects suffering from an acute cold with lower-airway symptoms. In addition, we assessed the repeatability in healthy controls.
methodsEBC was collected from 40 subjects (n = 10 in each of the above groups) using RTube and ECoScreen. EBC was collected from controls on two separate occasions within 5 days. pH in EBC was assessed after degasification with argon for 20 min.
resultsIn controls, pH-measurements in EBC collected by RTube or ECoScreen showed no significant difference between devices (p = 0.754) or between days (repeatability coefficient RTube: 0.47; ECoScreen: 0.42) of collection. A comparison between EBC pH collected by the two devices in asthma, COPD and cold patients also showed good reproducibility. No differences in pH values were observed between controls (mean pH 8.27; RTube) and patients with COPD (pH 7.97) or asthma (pH 8.20), but lower values were found using both devices in patients with a cold (pH 7.56; RTube, p < 0.01; ECoScreen, p < 0.05).
conclusionWe conclude that pH measurements in EBC collected by RTube and ECoScreen are repeatable and reproducible in healthy controls, and are reproducible and comparable in healthy controls, COPD and asthma patients, and subjects with a common cold.
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