ArticleOral microbiology and immunology2009
Oral bacteria induce a differential activation of human immunodeficiency virus-1 promoter in T cells, macrophages and dendritic cells.
Article in Oral microbiology and immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions.Life (Basel, Switzerland) · 2022Review
- SARS-CoV-2 Infection and Significance of Oral Health Management in the Era of "the New Normal with COVID-19".International journal of molecular sciences · 2021Review
- Oral commensal bacteria differentially modulate epithelial cell death.Archives of oral biology · 2020Article
- The influence of spaceflight on the astronaut salivary microbiome and the search for a microbiome biomarker for viral reactivation.Microbiome · 2020Article
- Current trends and new developments in HIV research and periodontal diseases.Periodontology 2000 · 2020Review
- Biomarkers of oral inflammation in perinatally HIV-infected and perinatally HIV-exposed, uninfected youth.Journal of clinical periodontology · 2019Article
- Alterations to the Gastrointestinal Microbiome Associated with Methamphetamine Use among Young Men who have Sex with Men.Scientific reports · 2019Article
- Polybacterial challenge enhances HIV reactivation in latently infected macrophages and dendritic cells.Immunology · 2011Article
- Bacterial and viral pathogens in saliva: disease relationship and infectious risk.Periodontology 2000 · 2011Review
- Polybacterial challenge effects on cytokine/chemokine production by macrophages and dendritic cells.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- The oral commensal, Streptococcus gordonii, synergizes with Tat protein to induce HIV-1 promoter activation in monocytes/macrophages.Cellular immunology · 2011Article
- HIV-1 reactivation induced by the periodontal pathogens Fusobacterium nucleatum and Porphyromonas gingivalis involves Toll-like receptor 2 [corrected] and 9 activation in monocytes/macrophages.Clinical and vaccine immunology : CVI · 2010Article
- Supernatants from oral epithelial cells and gingival fibroblasts modulate human immunodeficiency virus type 1 promoter activation induced by periodontopathogens in monocytes/macrophages.Molecular oral microbiology · 2010Article
- Herpesviral-bacterial interactions in periodontal diseases.Periodontology 2000 · 2010Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
introductionThe human immunodeficiency virus (HIV) can integrate into T cells, macrophages and dendritic cells resulting in a latent infection. Reports have also demonstrated that various microbial and host cell factors can trigger HIV reactivation leading to HIV recrudescence, potentially undermining highly active antiretroviral therapies.
methodsThis study evaluated the capacity of oral bacteria associated with chronic periodontal infections to stimulate HIV promoter activation in various cell models of HIV latency.
resultsT cells (1G5) challenged with oral bacteria demonstrated a dose-response of HIV promoter activation with a subset of the bacteria, as well as kinetics that were generally similar irrespective of the stimuli. Direct bacterial challenge of the T cells resulted in increased activation of approximately 1.5- to 7-fold over controls. Challenge of macrophages (BF24) indicated different kinetics for individual bacteria and resulted in consistent increases in promoter activation of five fold to six fold over basal levels for all bacteria except Streptococcus mutans. Dendritic cells showed increases in HIV reactivation of 7- to 34-fold specific for individual species of bacteria.
conclusionThese results suggested that oral bacteria have the capability to reactivate HIV from latently infected cells, showing a relationship of mature dendritic cells > immature dendritic cells > macrophages > or = T cells. Expression of various pattern recognition receptors on these various cell types may provide insight into the primary receptors/signaling pathways used for reactivation by the bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.