Evidence map›Paper›PMID 19702409›Full record

SynthesisNeuropsychology2009

A meta-analytic investigation of neurocognitive deficits in bipolar illness: profile and effects of clinical state.

Matthew M Kurtz, Raphael T Gerraty

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuropsychology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 5 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 5 syntheses or guidelines pooled it, 419 citations in OpenAlex.

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  15. Risk Factors Associated with Longitudinal Trajectories of Mania Symptoms in Youth.medRxiv : the preprint server for health sciences · 2026
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88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Matthew M KurtzDepartment of Psychology and Program in Neuroscience and Behavior, Wesleyan University, Middletown, CT 06459, USA. mkurtz@wesleyan.edu
Raphael T Gerraty
Wesleyan University · US

Funding

Neurocognitive Rehabilitation for SchizophreniaK08MH069888 · NIMH · WESLEYAN UNIVERSITY · PI KURTZ, MATTHEW M · 2005 to 2009
$749k
NIMH NIH HHS K08 MH069888NIMH NIH HHS K08 MH-69888
6 · The paper itself

Abstract

A meta-analysis of neuropsychological studies of patients with bipolar disorder comprised of 42 studies of 1,197 patients in euthymia, 13 studies consisting of 314 patients in a manic/mixed phase of illness, and 5 studies of 96 patients in a depressed state. Cohen d values were calculated for each study as the mean difference between patient and control group score on each neuropsychological measure, expressed in pooled SD units. For euthymia, results revealed impairment across all neuropsychological domains, with d values in the moderate-to-large range (d = .5 - .8) for the vast majority of measures. There was evidence of large effect-size impairment on measures of verbal learning (d = .81), and delayed verbal and nonverbal memory (d = .80 - .92), while effect-size impairment on measures of visuospatial function was small-to-moderate (d <or= .55). Patients tested during a manic/mixed or depressed phase of illness showed exaggerated impairment on measures of verbal learning, whereas patients tested during a depressed phase showed greater decrement on measures of phonemic fluency. These results suggest that bipolar illness during euthymia is characterized by generalized moderate level of neuropsychological impairment with particular marked impairment in verbal learning and memory. These results also show that a subset of these deficits moderately worsen during acute disease states.

Indexed as

AttentionBipolar DisorderCognition DisordersConfidence IntervalsDepressionFemaleHumansMaleMEDLINEMemory, Short-TermNeuropsychological TestsOdds RatioProblem SolvingRetrospective StudiesVerbal Behavior

Identifiers

PMID19702409
PMCPMC2804472
OpenAlexW2027687863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.