ArticleAnalytical chemistry2009
Peptide photodissociation with 157 nm light in a commercial tandem time-of-flight mass spectrometer.
Article in Analytical chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Radical-Initiated Photodissociation at Tryptophan Residues within Intact Proteins in the Gas Phase.Journal of the American Chemical Society · 2025Article
- Advancing PROTAC Characterization: Structural Insights through Adducts and Multimodal Tandem-MS Strategies.Journal of the American Society for Mass Spectrometry · 2024Article
- Enhancing Biomolecule Analysis and 2DMS Experiments by Implementation of (Activated Ion) 193 nm UVPD on a FT-ICR Mass Spectrometer.Analytical chemistry · 2022Article
- Tandem-trapped ion mobility spectrometry/mass spectrometry coupled with ultraviolet photodissociation.Rapid communications in mass spectrometry : RCM · 2021Article
- Distinguishing Aspartic and Isoaspartic Acids in Peptides by Several Mass Spectrometric Fragmentation Methods.Journal of the American Society for Mass Spectrometry · 2016Article
- Combined Infrared Multiphoton Dissociation with Ultraviolet Photodissociation for Ubiquitin Characterization.Journal of the American Society for Mass Spectrometry · 2016Article
- Factors Affecting the Production of Aromatic Immonium Ions in MALDI 157 nm Photodissociation Studies.Journal of the American Society for Mass Spectrometry · 2016Article
- Photodissociation mass spectrometry: new tools for characterization of biological molecules.Chemical Society reviews · 2014Review
- Photodissociation of charge tagged peptides.Journal of the American Society for Mass Spectrometry · 2012Article
- Investigation of VUV Photodissociation Propensities Using Peptide Libraries.International journal of mass spectrometry · 2011Article
- Implementing photodissociation in an Orbitrap mass spectrometer.Journal of the American Society for Mass Spectrometry · 2011Article
- 193-nm photodissociation of singly and multiply charged peptide anions for acidic proteome characterization.Proteomics · 2011Article
- Ultraviolet photodissociation of carboxylate-derivatized peptides in a quadrupole ion trap.Journal of the American Society for Mass Spectrometry · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Photodissociation with 157 nm light was implemented in an ABI model 4700 matrix-assisted laser desorption ionization (MALDI) tandem time-of-flight (TOF) mass spectrometer for peptide analysis. With a homemade computer program to control the light timing based on the m/z of each precursor ion, the photodissociation setup was seamlessly automated with the mass spectrometer. Peptide photodissociation in this apparatus yielded fragments similar to those observed in previous experiments with a home-built tandem-TOF mass spectrometer. Peptides having arginine at their C-termini yielded high-energy x-, v-, and w- type fragments, while peptides with N-terminal arginine produced many a- and d- type ions. Abundant immonium ions were also generated. High-quality photodissociation spectra were obtained with as little as 5 fmol of peptides. In the analysis of various tryptic peptides, photodissociation provided much more sequence information than the conventional TOF-TOF collision induced dissociation (CID). Because of the high fragmentation efficiency, sensitivity was not sacrificed to achieve this.
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