ArticlePflugers Archiv : European journal of physiology2009
The progesterone receptor regulates the expression of TRPV4 channel.
Article in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- TRPV4 is involved in NLRP3 and NLRP1 inflammasomes activation after pilocarpine-induced status epilepticus in mice : Concise title: TRPV4-mediated inflammasome activation in epilepsy.Cellular and molecular life sciences : CMLS · 2026Article
- Going with the flow: New insights regarding flow induced KPhysiological reports · 2024Review
- Fallopian tube rheology regulates epithelial cell differentiation and function to enhance cilia formation and coordination.Nature communications · 2024Article
- The Potential of Infrared Thermography for Early Pregnancy Diagnosis in Nili-Ravi Buffaloes.Animals : an open access journal from MDPI · 2024Article
- Distribution and Assembly of TRP Ion Channels.Advances in experimental medicine and biology · 2021Article
- TRPV4 Increases the Expression of Tight Junction Protein-Encoding Genes via XBP1 in Mammary Epithelial Cells.Animals : an open access journal from MDPI · 2020Article
- Steroids and TRP Channels: A Close Relationship.International journal of molecular sciences · 2020Review
- Roles of steroid hormones in oviductal functionReproduction (Cambridge, England) · 2020Review
- Significance of transient receptor potential vanilloid 4 and aquaporin 5 co-expression in the rat uterus at term.Heliyon · 2019Article
- TRPV4 is involved in levonorgestrel-induced reduction in oviduct ciliary beating.The Journal of pathology · 2019Article
- Moderate High Temperature Condition Induces the Lactation Capacity of Mammary Epithelial Cells Through Control of STAT3 and STAT5 Signaling.Journal of mammary gland biology and neoplasia · 2018Article
- TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain.Frontiers in molecular biosciences · 2018Review
- The Transient Receptor Potential (TRP) Channel Family in Colletotrichum graminicola: A Molecular and Physiological Analysis.PloS one · 2016Article
- TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells.Pflugers Archiv : European journal of physiology · 2015Article
- Calcium influx pathways in breast cancer: opportunities for pharmacological intervention.British journal of pharmacology · 2014Review
- ΔFosB in the supraoptic nucleus contributes to hyponatremia in rats with cirrhosis.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Sex hormone-dependent regulation of cilia beat frequency in airway epithelium.American journal of respiratory cell and molecular biology · 2012Article
- Heritability of serum sodium concentration: evidence for sex- and ethnic-specific effects.Physiological genomics · 2012Article
- The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia.PloS one · 2012Article
- Sensory functions of motile cilia and implication for bronchiectasis.Frontiers in bioscience (Scholar edition) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transient receptor potential cationic channel TRPV4 contributes to different aspects of cell physiology via the generation of a Ca2+ signal and/or depolarization of the membrane potential. TRPV4 channel integrates distinct physical and chemical stimuli, including osmotic and mechanical stress, heat, acidic pH, endogenous ligands, and synthetic agonists such as 4alpha-phorbol 12,13-didecanoate (4alphaPDD). Although several regulatory sites controlling TRPV4 channel activity have been identified, very little is known about the regulation of TRPV4 expression, a situation common to other TRP channels. Here we show that TRPV4 expression is under the control of progesterone in both human airways and mammary gland epithelial cells, as well as in vascular smooth muscle cells. Exposure of human airways epithelial CFT1-LCFSN and mammary gland epithelial T47D cells to progesterone decreased TRPV4 mRNA and protein expression. Consequently, 4alphaPDD-induced cationic currents and Ca2+ signals were also diminished in progesterone-treated cells. The effect of progesterone was reverted by the progesterone receptor (PR) antagonist RU-486 or following transfection with small interference RNA (siRNA) against both PRA and PRB isoforms. Interestingly, TRPV4 expression and activity were increased in T47D mammary gland epithelial cells when PR was silenced with siRNA. Transcriptional regulation of -1.3 kB TRPV4 promoter-luciferase plasmids was also evaluated in vascular smooth muscle cells. TRPV4 promoter activity was reduced by coexpression with PR and further reduced in the presence of PG. Together, our data report the regulation of TRPV4 expression by progesterone, a process that requires a functional PR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.