ArticleExperimental brain research2009
Replacement of a single cysteine in the fourth transmembrane region of zebrafish pannexin 1 alters hemichannel gating behavior.
Article in Experimental brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts.Cell reports · 2023Article
- Panx1b Modulates the Luminance Response and Direction of Locomotion in the Zebrafish.International journal of molecular sciences · 2021Article
- Pannexin-1 Channel Regulates ATP Release in Epilepsy.Neurochemical research · 2020Review
- Role of an Aromatic-Aromatic Interaction in the Assembly and Trafficking of the Zebrafish Panx1a Membrane Channel.Biomolecules · 2020Article
- A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model.Frontiers in molecular neuroscience · 2018Article
- Calcium dynamics and regulation in horizontal cells of the vertebrate retina: lessons from teleosts.Journal of neurophysiology · 2017Review
- Pannexin channel and connexin hemichannel expression in vascular function and inflammation.BMC cell biology · 2017Review
- A new mode of SAM domain mediated oligomerization observed in the CASKIN2 neuronal scaffolding protein.Cell communication and signaling : CCS · 2016Article
- Structural and Functional Consequences of Connexin 36 (Cx36) Interaction with Calmodulin.Frontiers in molecular neuroscience · 2016Article
- Review
- Investigation of olfactory function in a Panx1 knock out mouse model.Frontiers in cellular neuroscience · 2014Article
- Connexin and Pannexin hemichannels are regulated by redox potential.Frontiers in physiology · 2014Review
- The pannexins: past and present.Frontiers in physiology · 2014Review
- Pannexin1 channel proteins in the zebrafish retina have shared and unique properties.PloS one · 2013Article
- Pannexin 1 ohnologs in the teleost lineage.The Journal of membrane biology · 2012Article
- Pannexin1-mediated ATP release provides signal transmission between Neuro2A cells.Neurochemical research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pannexin1 (Panx1) is a novel candidate for an electrical synapse protein in the retina. At present Panx1 is considered to function as a hemichannel. Since information about the gating properties of Panx1 channels to date rely on blocker pharmacology, we have begun to establish a structural context of channel function starting with site directed mutagenesis of cysteine residues in transmembrane domains of Panx1. Dye uptake and whole cell voltage clamp recordings of transfected N2a cells demonstrate that zfPanx1 forms voltage activated hemichannels with a large unitary conductance in vitro. The function of this channel was significantly reduced following mutation of a single cysteine residue (C282W) in the fourth transmembrane region. This result suggests a role of this domain in gating of the Panx1 hemichannel.
Indexed as
Identifiers
19701745What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.