ArticlePflugers Archiv : European journal of physiology2009
Reactive oxygen species activate the group IV muscle afferents in resting and exercising muscle in rats.
Article in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 51 citations in OpenAlex.
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- Neurovascular Dysregulation During Exercise in Type 2 Diabetes.Frontiers in physiology · 2021Review
- Ascorbate attenuates cycling exercise-induced neuromuscular fatigue but fails to improve exertional dyspnea and exercise tolerance in COPD.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Effects of acute hyperglycemia on the exercise pressor reflex in healthy rats.Autonomic neuroscience : basic & clinical · 2020Article
- Recent advances in exercise pressor reflex function in health and disease.Autonomic neuroscience : basic & clinical · 2020Review
- Exaggerated exercise pressor reflex in type 2 diabetes: Potential role of oxidative stress.Autonomic neuroscience : basic & clinical · 2019Review
- Understanding neuromuscular disorders in chronic fatigue syndrome.F1000Research · 2019Review
- Muscle fatigue: general understanding and treatment.Experimental & molecular medicine · 2017Review
- Hydrogen Peroxide Induces Muscle Nociception via Transient Receptor Potential Ankyrin 1 Receptors.Anesthesiology · 2017Article
- Exercise performance and physiological responses: the potential role of redox imbalance.Physiological reports · 2017Article
- Peripheral Mechanisms of Ischemic Myalgia.Frontiers in cellular neuroscience · 2017Review
- Angiotensin-dependent autonomic dysregulation precedes dilated cardiomyopathy in a mouse model of muscular dystrophy.Experimental physiology · 2015Article
- Chronic oral administration of Ang-(1-7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy.Clinical science (London, England : 1979) · 2014Article
- The link between stress disorders and autonomic dysfunction in muscular dystrophy.Frontiers in physiology · 2014Article
- Ascorbate infusion increases skeletal muscle fatigue resistance in patients with chronic obstructive pulmonary disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Effect of oxidative stress on sympathetic and renal vascular responses to ischemic exercise.Physiological reports · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We tested the hypothesis that the reactive oxygen species (ROS) produced at rest and mostly during muscle contraction may stimulate the group IV muscle afferents. In rats, afferent activity was recorded in the peroneal nerve innervating the tibialis anterior muscle. Group IV afferents were identified from measurements of their conduction velocity and response to lactic acid. Comparing the group IV response to an intramuscular injection of buffered isotonic NaCl solution, we searched for the effects of a ROS donor (H2O2) or a ROS inhibitor (superoxide dismutase, SOD) on the baseline afferent activity in resting muscles. We also explored the consequences of a pre-treatment with SOD on the afferent nerve response to H2O2 injection or electrical muscle stimulation (MS). In other animals, we measured the changes in intramuscular level of a marker of oxidative stress (isoprostanes) after each test agent. H2O2 injection markedly activated all recorded group IV afferents. SOD injection lowered the baseline activity of 50 out of 70 afferent units, suppressed the afferent response to H2O2 injection, and delayed and reduced the MS-induced activation of all recorded units. Intramuscular isoprostanes level significantly increased after H2O2 injection or MS, the oxidative stress being absent in muscles pre-treated with SOD. We concluded that ROS influence both the spontaneous and contraction-induced activities of the group IV muscle afferents and are a potent stimulus of muscle metaboreceptors.
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