Evidence map›Paper›PMID 19701632›Full record

ArticleExperimental brain research2009

θ burst and conventional low-frequency rTMS differentially affect GABAergic neurotransmission in the rat cortex.

Jörn Trippe, Annika Mix, Selcen Aydin-Abidin, Klaus Funke, Alia Benali

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Experimental brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01819675 (Effect of rTMS Over Primary Motor Cortex on Gamma-aminobutyric Acid A), which is not on this map. Cited by 84 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01819675 naterminatednot on this mapstarted 2013, after this paper: background citation

Effect of rTMS Over Primary Motor Cortex on Gamma-aminobutyric Acid A (GABAA)-[18F]Flumazenil Binding: A Positron Emission Tomography (PET) Study

TypeinterventionalSponsorSeoul National University Bundang HospitalRan2013 to 2016Enrolled6ConditionsStroke, HemiplegiaArmsLow frequency rTMS, High frequency rTMS, Sham rTMS
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 3 syntheses or guidelines pooled it, 171 citations in OpenAlex.

  1. Pooled it
  2. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Guideline
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Impairment of the GABAergic system in the prefrontal cortex of male heroin addicts.European archives of psychiatry and clinical neuroscience · 2026
    Article
  10. Impairment of the GABAergic system in the anterior midcingulate cortex of heroin-addicted males.European archives of psychiatry and clinical neuroscience · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Intrinsic Plasticity Mechanisms of Repetitive Transcranial Magnetic Stimulation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  17. Review
  18. Review
  19. Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jörn TrippeDepartment of Neurophysiology, Medical Faculty, Ruhr-University Bochum, 44780 Bochum, Germany.
Annika Mix
Selcen Aydin-Abidin
Klaus Funke
Alia Benali
Ruhr University Bochum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modified cortical excitability following repetitive transcranial magnetic stimulation (rTMS) may be related to short- or long-term synaptic plasticity of neuronal excitation but could also affect cortical inhibition. Therefore, in the rat we tested how three different rTMS protocols, intermittent and continuous theta-burst (iTBS, cTBS), and low-frequency 1 Hz stimulation, change the expression of GAD65, GAD67 and GAT-1 which are expressed in cortical inhibitory interneurons in an activity-dependent manner. Acutely (2 h), all protocols reduced the expression of GAD67 in frontal, motor, somatosensory and visual cortex but increased that of GAD65 and GAT-1 to different degree, with iTBS having the strongest acute effect. The initial decrease in GAD67 reversed after 1 day, leading to a strong increase in GAD67 expression for up to 7 days primarily in the frontal cortex in case of iTBS, cTBS and in all studied areas following 1 Hz rTMS. While also GAD65 and GAT-1 expression reversed after 1 day in case of iTBS and cTBS, 1 Hz rTMS induced a steady increase in GAD65 and GAT-1 expression during the 7 days investigated. Our data demonstrate that rTMS affects the expression of activity-dependent proteins of the cortical inhibitory interneurons. Besides common effects of low- (1 Hz) and high-frequency (TBS) stimulation on protein expression, differences in quantity and time course of changes point to differences in the contribution of possible neuronal subsystems. Further studies are needed to distinguish cell-type specific effects.

Indexed as

AnimalsCerebral Cortexgamma-Aminobutyric AcidMaleRatsSynaptic TransmissionTheta RhythmTranscranial Magnetic Stimulationgamma-Aminobutyric Acid

Identifiers

PMID19701632
OpenAlexW2093389758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.