ArticleJournal of gastroenterology2009
Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis.
Article in Journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- The Role of GI Peptides in Functional Dyspepsia and Gastroparesis: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Helicobacter pylori infection and circulating ghrelin levels - a systematic review.BMC gastroenterology · 2011Pooled it
- The association between blood lipid levels and the risk of atrophic gastritis: a cross-sectional study of the Wuwei cohort.Frontiers in public health · 2026Article
- Association betweenFrontiers in endocrinology · 2023Article
- Development of plasma ghrelin level as a novel marker for gastric mucosal atrophy afterAnnals of medicine · 2022Article
- Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease.International journal of molecular sciences · 2021Review
- Precision Medicine Approaches to Prevent Gastric Cancer.Gut and liver · 2021Review
- Eradication therapy forJournal of clinical biochemistry and nutrition · 2019Article
- Influence of the Degree of Gastric Mucosal Atrophy on the Serum Lipid Levels Before and After the Eradication of Helicobacter pylori Infection.Internal medicine (Tokyo, Japan) · 2018Article
- Low PG I/II ratio as a marker of atrophic gastritis: Association with nutritional and metabolic status in healthy people.Medicine · 2018Observational
- Effects ofJournal of clinical biochemistry and nutrition · 2018Article
- Nutrition status andWorld journal of gastroenterology · 2018Review
- Population screening and treatment of Helicobacter pylori infection.Nature reviews. Gastroenterology & hepatology · 2017Review
- Article
- Atrophic and Metaplastic Progression in the Background Mucosa of Patients with Gastric Adenoma.PloS one · 2017Article
- Changes in plasma ghrelin and leptin levels in patients with peptic ulcer and gastritis following eradication of Helicobacter pylori infection.BMC gastroenterology · 2016Article
- The Association between Helicobacter pylori Infection and Body Weight among Children.Pediatric gastroenterology, hepatology & nutrition · 2016Article
- Increase in plasma acyl ghrelin levels is associated with abatement of dyspepsia following Helicobacter pylori eradication.Journal of gastroenterology · 2016Article
- Changes in Metabolic Hormones in Malaysian Young Adults following Helicobacter pylori Eradication.PloS one · 2015Article
- Can Helicobacter pylori infection influence human reproduction?World journal of gastroenterology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe attempted to clarify the significance of atrophic change of gastric mucosa for reduction of plasma ghrelin concentration irrespective of Helicobacter pylori (Hp) infection.
methodsPlasma acylated (acyl-)ghrelin concentration in 220 subjects, both with and without atrophic gastritis, was measured with an enzyme immunoassay kit. The extent of atrophic change of gastric mucosa was assessed and graded endoscopically. Hp infection was determined by assay of the anti-Hp antibody with an ELISA assay kit.
resultsPlasma acyl-ghrelin concentration was significantly lower in the Hp positive than the Hp negative group, and Hp eradication significantly increased plasma acyl-ghrelin concentrations in Hp positive subjects. Plasma acyl-ghrelin was significantly lower in subjects with severely atrophic gastritis than in those with mild or moderate atrophic gastritis, irrespective of Hp infection or age group (<60 years old or > or = 60 years old). In male subjects with a normal body mass index, plasma acyl-ghrelin concentrations in subjects with severely atrophic gastritis were significantly lower than those in subjects with mildly or moderately atrophic gastritis, suggesting that the results of the study are independent of emaciation or obesity. Logistic regression analysis showed that gastric atrophy is the key factor that modulates plasma acyl-ghrelin levels.
conclusionsThe results suggest that plasma acyl-ghrelin concentration decreases in accordance with the extent of atrophic change in gastric mucosa irrespective of Hp infection, indicating that the low plasma acyl-ghrelin level of subjects with Hp infection is mainly caused by the progress of atrophic changes in gastric mucosa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.