ArticleTranslational oncology2009
Altered microRNA Expression Patterns in Hepatoblastoma Patients.
Article in Translational oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 73 citations in OpenAlex.
- First Transcriptome Analysis of Hepatoblastoma in Brazil: Unraveling the Pivotal Role of Noncoding RNAs and Metabolic Pathways.Biochemical genetics · 2025Article
- Metabolic and Epigenetic Mechanisms in Hepatoblastoma: Insights into Tumor Biology and Therapeutic Targets.Genes · 2024Review
- Children's Oncology Group's 2023 blueprint for research: Liver tumors.Pediatric blood & cancer · 2023Article
- Association between diminished miRNA expression and the disease status of AML patients: Comparing to healthy control.Biomedical journal · 2023Article
- Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets.Functional & integrative genomics · 2023Review
- miRNAs as Biomarkers and Possible Therapeutic Strategies in Synovial Sarcoma.Frontiers in pharmacology · 2022Review
- Identification of potential key genes and miRNAs involved in Hepatoblastoma pathogenesis and prognosis.Journal of cell communication and signaling · 2021Article
- Diagnostic value and prognostic significance of LI-cadherin and miR-378e in colorectal cancer.Oncology letters · 2020Article
- MicroRNAs and Long Non-coding RNAs in Genetic Diseases.Molecular diagnosis & therapy · 2019Review
- The Role of MicroRNAs in Hepatoblastoma Tumors.Cancers · 2019Review
- Dysregulated microRNA expression profiles in gastric cancer cells with high peritoneal metastatic potential.Experimental and therapeutic medicine · 2018Article
- MicroRNA therapy inhibits hepatoblastoma growthHepatology communications · 2017Article
- Regulatory network analysis of genes and microRNAs in human hepatoblastoma.Oncology letters · 2016Article
- Isolation and characterization of vesicular and non-vesicular microRNAs circulating in sera of partially hepatectomized rats.Scientific reports · 2016Article
- microRNA changes in liver tissue associated with fibrosis progression in patients with hepatitis C.Liver international : official journal of the International Association for the Study of the Liver · 2016Article
- Role of microRNA-150 in solid tumors.Oncology letters · 2015Article
- A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients.Scientific reports · 2015Article
- microRNA-148a inhibits hepatocellular carcinoma cell invasion by targeting sphingosine-1-phosphate receptor 1.Experimental and therapeutic medicine · 2015Article
- Genome-Wide Expression of MicroRNAs Is Regulated by DNA Methylation in Hepatocarcinogenesis.Gastroenterology research and practice · 2015Article
- Multi-platform microRNA profiling of hepatoblastoma patients using formalin fixed paraffin embedded archival samples.GigaScience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver cancers in children are rare representing only 1.1% of malignancies, with an annual incidence rate of 1.5 cases per million. Hepatoblastoma and hepatocellular carcinomas are the most common malignancies of the liver occurring in young people aged 15 years or younger. Molecular basis of both tumors are still unclear, and common markers (i.e., CTNNB1, APC, IGF-2) are not always useful in the characterization of sporadic forms; in this respect, microRNA recently associated with carcinogenesis could play a pivotal role in their onset. CTNNB1 and APC were analyzed by sequencing, and IGF-2 promoter methylation status was assessed by methylation-specific polymerase chain reaction. MicroRNA expression was assayed by microarray and quantitative reverse transcription-polymerase chain reaction in hepatoblastoma samples. Although few genomic alterations were detected in ours samples, an altered expression of somemicroRNA in hepatoblastoma was observed. Unsupervised clustering shows that microRNA profile can distinguish tumor from nontumor tissues. Further analyses of microRNA contents in hepatoblastoma compared with hepatocellular carcinoma highlighted four upregulated microRNA (miR-214, miR-199a, miR-150 [P < .01], and miR-125a [P < .05]) and one downregulated microRNA (miR-148a [P < .01]). In conclusion, although our samples were poorly informative from a genetic point of view, they showed a peculiar microRNA expression pattern compared with nontumor tissues and hepatocellular carcinoma. MicroRNA could represent valid markers for the classification of pediatric liver tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.