Trial reportObstetrics and gynecology2009
Effects of periodontal therapy on rate of preterm delivery: a randomized controlled trial.
Trial report in Obstetrics and gynecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03381469 (Association Between Periodontitis and Adverse Pregnancy Outcomes in Metabolic Syndrome Patients- Interventional Study), which is not on this map. Cited by 84 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between Periodontitis and Adverse Pregnancy Outcomes in Metabolic Syndrome Patients- Interventional Study
Who cites it
84 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- The association between periodontal disease and adverse pregnancy outcomes: a bibliometric analysis from 2000 to 2023.Frontiers in medicine · 2025Pooled it
- Effect of Treating Periodontal Disease in Pregnant Women to Reduce the Risk of Preterm Birth and Low Birth Weight: An Umbrella Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Effects of different periodontal interventions on the risk of adverse pregnancy outcomes in pregnant women: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in public health · 2024Pooled it
- Association of Chlorhexidine Use and Scaling and Root Planing With Birth Outcomes in Pregnant Individuals With Periodontitis: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Prenatal Oral Health Care and Early Childhood Caries Prevention: A Systematic Review and Meta-Analysis.Caries research · 2019Pooled it
- Treating periodontal disease for preventing adverse birth outcomes in pregnant women.The Cochrane database of systematic reviews · 2017Pooled it
- Periodontal treatment for preventing adverse pregnancy outcomes: a meta- and trial sequential analysis.PloS one · 2015Pooled it
- Maternal periodontal disease and risk of preeclampsia: a meta-analysis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014Pooled it
- The potential association between gingival crevicular fluid inflammatory mediators and adverse pregnancy outcomes: a systematic review.Clinical oral investigations · 2013Pooled it
- Effectiveness of interventions to screen and manage infections during pregnancy on reducing stillbirths: a review.BMC public health · 2011Pooled it
- Obstetric outcomes after treatment of periodontal disease during pregnancy: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2010Pooled it
- Trial
- Adherence to and acceptability of three alcohol-free, antiseptic oral rinses: A community-based pilot randomized controlled trial among pregnant women in rural Nepal.Community dentistry and oral epidemiology · 2020Trial
- Non-Surgical Treatment of Periodontal Disease in a Pregnant Caucasian Women Population: Adverse Pregnancy Outcomes of a Randomized Clinical Trial.International journal of environmental research and public health · 2019Trial
- Use of mouth rinse during pregnancy to improve birth and neonatal outcomes: a randomized controlled trial.BMC pregnancy and childbirth · 2015Trial
- Periodontal treatment outcomes during pregnancy and postpartum.Clinical oral investigations · 2015Trial
- Trial
- Effect of intensive oral hygiene regimen during pregnancy on periodontal health, cytokine levels, and pregnancy outcomes: a pilot study.Journal of periodontology · 2014Trial
- A randomized controlled trial of pre-conception treatment for periodontal disease to improve periodontal status during pregnancy and birth outcomes.BMC pregnancy and childbirth · 2013Trial
- Effect of nonsurgical periodontal therapy and strict plaque control on preterm/low birth weight: a randomized controlled clinical trial.Clinical oral investigations · 2013Trial
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
objectiveTo test the effects of maternal periodontal disease treatment on the incidence of preterm birth (delivery before 37 weeks of gestation).
methodsThe Maternal Oral Therapy to Reduce Obstetric Risk Study was a randomized, treatment-masked, controlled clinical trial of pregnant women with periodontal disease who were receiving standard obstetric care. Participants were assigned to either a periodontal treatment arm, consisting of scaling and root planing early in the second trimester, or a delayed treatment arm that provided periodontal care after delivery. Pregnancy and maternal periodontal status were followed to delivery and neonatal outcomes until discharge. The primary outcome (gestational age less than 37 weeks) and the secondary outcome (gestational age less than 35 weeks) were analyzed using a chi test of equality of two proportions.
resultsThe study randomized 1,806 patients at three performance sites and completed 1,760 evaluable patients. At baseline, there were no differences comparing the treatment and control arms for any of the periodontal or obstetric measures. The rate of preterm delivery for the treatment group was 13.1% and 11.5% for the control group (P=.316). There were no significant differences when comparing women in the treatment group with those in the control group with regard to the adverse event rate or the major obstetric and neonatal outcomes.
conclusionPeriodontal therapy did not reduce the incidence of preterm delivery. LEVEL OF EVIDENCE: I.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.