ArticleThe American journal of pathology2009
Relationships between deficits in tissue mass and transcriptional programs after partial hepatectomy in mice.
Article in The American journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Epigenetic Compensation Promotes Liver Regeneration.Developmental cell · 2019Article
- Dynamics of macrophage populations of the liver after subtotal hepatectomy in rats.BMC immunology · 2018Article
- Ductular reactions in the liver regeneration process with local inflammation after physical partial hepatectomy.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- Molecular Survey of Cell Source Usage during Subtotal Hepatectomy-Induced Liver Regeneration in Rats.PloS one · 2016Article
- A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation.Genes & development · 2015Article
- A Systems Biology Study on NFκB Signaling in Primary Mouse Hepatocytes.Frontiers in physiology · 2012Article
- Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- New concepts in liver regeneration.Journal of gastroenterology and hepatology · 2011Article
- Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice.Hepatology (Baltimore, Md.) · 2010Article
- Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice.PloS one · 2010Article
- MicroRNAs control hepatocyte proliferation during liver regeneration.Hepatology (Baltimore, Md.) · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Liver regeneration after two-thirds partial hepatectomy (2/3 PH) results in synchronized proliferation of hepatocytes and rapid restoration of liver mass. Understanding the mechanisms that regulate this process has both biological and clinical importance. Using cDNA microarray analysis, we investigated whether gene activation after 2/3 PH is specifically related to liver growth and hepatocyte proliferation. We generated gene expression profiles at 4, 12, 20, and 30 hours after 2/3 PH and compared them with profiles obtained at the same time points after 1/3 PH, a procedure that causes minimal DNA replication. Surprisingly, a significant number of genes whose expression is altered after 2/3 PH are similarly up- or down-regulated after 1/3 PH, particularly at 4 hours. We identified a number of genes and transcription factors that are more highly expressed ("preferential expression") after 2/3 PH and show that a shift in transcriptional programs in the regenerating liver occurs between 4 and 12 hours after 2/3 PH, a time at which the decision to replicate appears to be made. These results show that the liver responds to PH with massive changes of gene expression, even in the absence of DNA replication. We suggest that the changes in gene expression during the first 4 to 6 hours after 2/3 PH may induce chromatin remodeling and facilitate the binding of new sets of transcription factors required for DNA replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.