ArticleDevelopment (Cambridge, England)2009
Evolving enhancer-promoter interactions within the tinman complex of the flour beetle, Tribolium castaneum.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
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- Multiscale analysis of the randomization limits of the chromosomal gene organization between Lepidoptera and Diptera.Proceedings. Biological sciences · 2022Article
- Genome structure variation analyses of peach reveal population dynamics and a 1.67 Mb causal inversion for fruit shape.Genome biology · 2021Article
- Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks.Genome research · 2019Article
- Enhancer adoption caused by genomic insertion elicits interdigitalProceedings of the National Academy of Sciences of the United States of America · 2018Article
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- Homeodomain proteins: an update.Chromosoma · 2016Review
- Evolution of lineage-specific functions in ancient cis-regulatory modules.Open biology · 2015Article
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- Unraveling the Tangled Skein: The Evolution of Transcriptional Regulatory Networks in Development.Annual review of genomics and human genetics · 2015Review
- Wnt/β-catenin signaling integrates patterning and metabolism of the insect growth zone.Development (Cambridge, England) · 2014Article
- Evidence for deep regulatory similarities in early developmental programs across highly diverged insects.Genome biology and evolution · 2014Article
- Functional and topological characteristics of mammalian regulatory domains.Genome research · 2014Article
- Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Assessing constraints on the path of regulatory sequence evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- Evolution of transcriptional enhancers and animal diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- From remote enhancers to gene regulation: charting the genome's regulatory landscapes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Transcriptional repression via antilooping in the Drosophila embryo.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Analysis of the enhancer-blocking function of the TBS element from Petunia hybrida in transgenic Arabidopsis thaliana and Nicotiana tabacum.Plant cell reports · 2011Article
- Complex interactions between cis-regulatory modules in native conformation are critical for Drosophila snail expression.Development (Cambridge, England) · 2011Article
Corrections and comments
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3 authors at 1 institution in 2 countries.
Funding
Abstract
Modifications of cis-regulatory DNAs, particularly enhancers, underlie changes in gene expression during animal evolution. Here, we present evidence for a distinct mechanism of regulatory evolution, whereby a novel pattern of gene expression arises from altered gene targeting of a conserved enhancer. The tinman gene complex (Tin-C) controls the patterning of dorsal mesodermal tissues, including the dorsal vessel or heart in Drosophila. Despite broad conservation of Tin-C gene expression patterns in the flour beetle (Tribolium castaneum), the honeybee (Apis mellifera) and the fruit fly (Drosophila melanogaster), the expression of a key pericardial determinant, ladybird, is absent from the dorsal mesoderm of Tribolium embryos. Evidence is presented that this loss in expression is replaced by expression of C15, the neighboring gene in the complex. This switch in expression from ladybird to C15 appears to arise from an inversion within the tinman complex, which redirects a conserved ladybird 3' enhancer to regulate C15. In Drosophila, this enhancer fails to activate C15 expression owing to the activity of an insulator at the intervening ladybird early promoter. By contrast, a chromosomal inversion allows the cardiac enhancer to bypass the ladybird insulator in Tribolium. Given the high frequency of genome rearrangements in insects, it is possible that such enhancer switching might be widely used in the diversification of the arthropods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.