ArticleDevelopment (Cambridge, England)2009
Extra-embryonic syndecan 2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryo.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 68 citations in OpenAlex.
- Regulated HSPG Signaling Directs Epicardial Behavior to Support Cardiac Formation.Circulation research · 2026Article
- Targeting syndecan-2 inhibits papillary thyroid cancer invasiveness and de-differentiation.BMC endocrine disorders · 2025Article
- A high-definition spatiotemporal transcriptomic atlas of mammalian kidney development.Innovation (Cambridge (Mass.)) · 2025Article
- Article
- Integrated single-cell RNA sequencing analysis reveals a mesenchymal stem cell-associated signature for estimating prognosis and drug sensitivity in gastric cancer.Journal of cancer research and clinical oncology · 2023Article
- The myocardium utilizes Pdgfra-PI3K signaling to steer towards the midline during heart tube formation.bioRxiv : the preprint server for biology · 2023Article
- Identifying multicellular spatiotemporal organization of cells with SpaceFlow.Nature communications · 2022Article
- Coreceptor functions of cell surface heparan sulfate proteoglycans.American journal of physiology. Cell physiology · 2022Review
- Analyzing the Role of Heparan Sulfate Proteoglycans in Axon Guidance In Vivo in Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The Heparan Sulfate Binding Peptide in Tumor Progression of Triple-Negative Breast Cancer.Frontiers in oncology · 2021Article
- Cardiac Fibroblasts and the Extracellular Matrix in Regenerative and Nonregenerative Hearts.Journal of cardiovascular development and disease · 2019Review
- Tmem2 regulates cell-matrix interactions that are essential for muscle fiber attachment.Development (Cambridge, England) · 2016Article
- Syndecan-4 modulates the proliferation of neural cells and the formation of CaP axons during zebrafish embryonic neurogenesis.Scientific reports · 2016Article
- Sterol O-Acyltransferase 2 Contributes to the Yolk Cholesterol Trafficking during Zebrafish Embryogenesis.PloS one · 2016Article
- Strategies for analyzing cardiac phenotypes in the zebrafish embryo.Methods in cell biology · 2016Article
- Heparan sulfate proteoglycans: a sugar code for vertebrate development?Development (Cambridge, England) · 2015Review
- Endoderm convergence controls subduction of the myocardial precursors during heart-tube formation.Development (Cambridge, England) · 2015Article
- Fell-Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra.International journal of experimental pathology · 2015Article
- The endoderm and myocardium join forces to drive early heart tube assembly.Developmental biology · 2015Article
- Analyzing the role of heparan sulfate proteoglycans in axon guidance in vivo in zebrafish.Methods in molecular biology (Clifton, N.J.) · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
One of the first steps in zebrafish heart and gut organogenesis is the migration of bilateral primordia to the midline to form cardiac and gut tubes. The mechanisms that regulate this process are poorly understood. Here we show that the proteoglycan syndecan 2 (Sdc2) expressed in the extra-embryonic yolk syncytial layer (YSL) acts locally at the YSL-embryo interface to direct organ primordia migration, and is required for fibronectin and laminin matrix assembly throughout the embryo. Surprisingly, neither endogenous nor exogenous sdc2 expressed in embryonic cells can compensate for knockdown of sdc2 in the YSL, indicating that Sdc2 expressed in extra-embryonic tissues is functionally distinct from Sdc2 in embryonic cells. The effects of sdc2 knockdown in the YSL can be rescued by extra-embryonic Sdc2 lacking an extracellular proteolytic cleavage (shedding) site, but not by extra-embryonic Sdc2 lacking extracellular glycosaminoglycan (GAG) addition sites, suggesting that distinct GAG chains on extra-embryonic Sdc2 regulate extracellular matrix assembly, cell migration and epithelial morphogenesis of multiple organ systems throughout the embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.