ArticleApplied and environmental microbiology2009
Cryptic lineages of the genus Escherichia.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
134 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A guide to the natural history of freshwater lake bacteria.Microbiology and molecular biology reviews : MMBR · 2011Pooled it
- Comparative analysis of antimicrobial resistance in enterotoxigenic Escherichia coli isolates from two paediatric cohort studies in Lima, Peru.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2015Trial
- From Cryptic Clade to Emerging Pathogen: Exploring the Evolutionary Divergence and Clinical Relevance ofMicroorganisms · 2026Review
- Antibiotic Resistance and Virulence Genes in Escherichia coli from Wild Birds in a Peruvian Wetland.EcoHealth · 2026Article
- Escherichia marmotae: a multidrug-resistant opportunistic human pathogen - first clinical isolation in the Czech Republic.Folia microbiologica · 2026Article
- Tryptophanase disruption promotes insect-bacterium mutualism.Nature microbiology · 2026Article
- Global genomic insights into the antimicrobial resistance ofZoological research · 2025Article
- Diversity of Environmental Escherichia coli in Subtropical Freshwater Systems of South Africa.Current microbiology · 2025Article
- Genomic Features of E. ruysiae Associated with the Ecological Origin: Implications for the Environmental Hypothesis.Current microbiology · 2025Article
- New diagnostic methods forFrontiers in microbiology · 2025Article
- Genome organization, virulence genes, and temperature-dependent motility of an emerging pathogen,Frontiers in microbiology · 2025Article
- Metabolic rearrangement enables adaptation of microbial growth rate to temperature shifts.Nature microbiology · 2025Article
- Impact of land-use and fecal contamination on Escherichia populations in environmental samples.Scientific reports · 2024Article
- Abundance of fecal indicator bacteria and diversity of Escherichia coli associated with poultry farms and pasture land cover in streams of northwestern South Carolina.Environmental monitoring and assessment · 2024Article
- Metagenomic evaluation of bacteria in drinking water using full-length 16S rRNA amplicons.Journal of water and health · 2024Article
- Population structure and pathogen interaction of Escherichia coli in freshwater: Implications of land-use for water quality and public health in Aotearoa New Zealand.Environmental microbiology reports · 2024Article
- ColiSeq: a multiplex amplicon assay that provides strain level resolution ofMicrobiology spectrum · 2024Article
- Novel multiplex-PCR test forMicrobiology spectrum · 2024Article
- Draft genome sequences ofMicrobiology resource announcements · 2024Article
- Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extended multilocus sequence typing (MLST) analysis of atypical Escherichia isolates was used to identify five novel phylogenetic clades (CI to CV) among isolates from environmental, human, and animal sources. Analysis of individual housekeeping loci showed that E. coli and its sister clade, CI, remain largely indistinguishable and represent nascent evolutionary lineages. Conversely, clades of similar age (CIII and CIV) were found to be phylogenetically distinct. When all Escherichia lineages (named and unnamed) were evaluated, we found evidence that Escherichia fergusonii has evolved at an accelerated rate compared to E. coli, CI, CIII, CIV, and CV, suggesting that this species is younger than estimated by the molecular clock method. Although the five novel clades were phylogenetically distinct, we were unable to identify a discriminating biochemical marker for all but one of them (CIII) with traditional phenotypic profiling. CIII had a statistically different phenotype from E. coli that resulted from the loss of sucrose and sorbitol fermentation and lysine utilization. The lack of phenotypic distinction has likely hindered the ability to differentiate these clades from typical E. coli, and so their ecological significance and importance for applied and clinical microbiology are yet to be determined. However, our sampling suggests that CIII, CIV, and CV represent environmentally adapted Escherichia lineages that may be more abundant outside the host gastrointestinal tract.
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Registered trials
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