Evidence map›Paper›PMID 19700364›Full record

ReviewCurrent opinion in chemical biology2009

Determination of glycosylation sites and site-specific heterogeneity in glycoproteins.

Hyun Joo An, John W Froehlich, Carlito B Lebrilla

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Glycan Sequencing, A Brief Primer.Glycoscience & therapy · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Uncovering a Latent Bioactive Interleukin-6 Glycoform.Angewandte Chemie (International ed. in English) · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Post-translational modifications in the Protein Data Bank.Acta crystallographica. Section D, Structural biology · 2024
    Review
  19. Review
  20. Article

79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hyun Joo AnDepartment of Chemistry, University of California, Davis, CA 95616, USA.
John W Froehlich
Carlito B Lebrilla

Funding

The incorporation of human milk oligosaccharides in brain glycoconjugatesR01GM049077 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI LEBRILLA, CARLITO B · 1999 to 2024
$6.3M
Structures, Functions, & Genetic Diversity of Oligosaccharides in MilkR01HD061923 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEBRILLA, CARLITO B · 2009 to 2013
$1.6M
NICHD NIH HHS R01 HD061923NIGMS NIH HHS R01 GM 049077NIGMS NIH HHS R01 GM049077
6 · The paper itself

Abstract

Glycosylation is one of the most common post-translational modifications (PTMs) of proteins. At least 50% of human proteins are glycosylated with some estimates being as high as 70%. Glycoprotein analysis requires determining both the sites of glycosylation as well as the glycan structures associated with each site. Recent advances have led to the development of new analytical methods that employ mass spectrometry extensively making it possible to obtain the glycosylation site and the site microheterogeneity. These tools will be important for the eventual development of glycoproteomics.

Indexed as

AnimalsGlycoproteinsGlycosylationHumansMass SpectrometryPolysaccharidesProtein Processing, Post-TranslationalProteomicsGlycoproteinsPolysaccharides

Identifiers

PMID19700364
PMCPMC2749913

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.