ReviewCurrent opinion in biotechnology2009
Generation of new protein functions by nonhomologous combinations and rearrangements of domains and modules.
Review in Current opinion in biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Design of structurally distinct proteins using strategies inspired by evolution.Science (New York, N.Y.) · 2016Article
- Design of catalytically amplified sensors for small molecules.Biomolecules · 2014Review
- Thermodynamic basis for engineering high-affinity, high-specificity binding-induced DNA clamp nanoswitches.ACS nano · 2013Article
- A structural bioinformatics approach for identifying proteins predisposed to bind linear epitopes on pre-selected target proteins.Protein engineering, design & selection : PEDS · 2013Article
- Article
- Generation of high-performance binding proteins for peptide motifs by affinity clamping.Methods in enzymology · 2013Article
- Protein domain recurrence and order can enhance prediction of protein functions.Bioinformatics (Oxford, England) · 2012Article
- Designing redox potential-controlled protein switches based on mutually exclusive proteins.Protein science : a publication of the Protein Society · 2012Article
- Protein conformational switches: from nature to design.Chemistry (Weinheim an der Bergstrasse, Germany) · 2012Review
- The dynamics and evolutionary potential of domain loss and emergence.Molecular biology and evolution · 2012Article
- Structure of an engineered β-lactamase maltose binding protein fusion protein: insights into heterotropic allosteric regulation.PloS one · 2012Article
- Molecular basis of a million-fold affinity maturation process in a protein-protein interaction.Journal of molecular biology · 2011Article
- Molecular simulations of mutually exclusive folding in a two-domain protein switch.Biophysical journal · 2011Article
- Converting a protein into a switch for biosensing and functional regulation.Protein science : a publication of the Protein Society · 2011Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Generation of novel protein functions is a major goal in biotechnology and also a rigorous test for our understanding of the relationship between protein structure and function. Early examples of protein engineering focused on design and directed evolution within the constraints of the original protein architecture, exemplified by the highly successful fields of antibody and enzyme engineering. Recent studies show that protein engineering strategies which step away from these natural architectures, that is by manipulating the organization of domains and modules thus mimicking nonhomologous recombination, are highly effective in producing complex and sophisticated functions in terms of both molecular recognition and regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.