Evidence map›Paper›PMID 19700145›Full record

ArticleEnvironmental research2009

Residential proximity to agricultural pesticide applications and childhood acute lymphoblastic leukemia.

Rudolph P Rull, Robert Gunier, Julie Von Behren, Andrew Hertz, Vonda Crouse, Patricia A Buffler, Peggy Reynolds

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Environmental research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00015587 (Chemical Exposures and Leukemia Risks and Childhood Leukemia and Environmental Exposure), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00015587 completednot on this map

Chemical Exposures and Leukemia Risks and Childhood Leukemia and Environmental Exposure

TypeobservationalSponsorNational Institute of Environmental Health Sciences (NIEHS)Ran1995 to 2016Enrolled3,523ConditionsLeukemia, Acute Myelocytic Leukemia, Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Biomedicines · 2025
    Review
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Article
  10. Residential proximity to croplands at birth and childhood leukaemia.Environmental health : a global access science source · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Rudolph P RullNorthern California Cancer Center, 2001 Center Street, Suite 700, Berkeley, CA 94704, USA. rrull@nccc.org
Robert Gunier
Julie Von Behren
Andrew Hertz
Vonda Crouse
Patricia A Buffler
Peggy Reynolds
Cancer Prevention Institute of California · USChildren's Hospital Central California · USNiagara County Community College · USNorthern California Research · USUniversity of California, Berkeley · US

Funding

Environmental and Molecular Epidemiology of Childhood LeukemiaR01ES009137 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 1999 to 2013
$21.1M
Exposure Insights Using GIS in a Case-Control StudyR01CA092674 · NCI · IMPACT ASSESSMENT, INC. · PI REYNOLDS, PEGGY · 2002 to 2006
$1.6M
NCI NIH HHS R01 CA092674NCI NIH HHS R01-CA92674NIEHS NIH HHS R01 ES009137NIEHS NIH HHS R01-ES09137
6 · The paper itself

Abstract

Ambient exposure from residential proximity to applications of agricultural pesticides may contribute to the risk of childhood acute lymphoblastic leukemia (ALL). Using residential histories collected from the families of 213 ALL cases and 268 matched controls enrolled in the Northern California Childhood Leukemia Study, the authors assessed residential proximity within a half-mile (804.5m) of pesticide applications by linking address histories with reports of agricultural pesticide use. Proximity was ascertained during different time windows of exposure, including the first year of life and the child's lifetime through the date of diagnosis for cases or reference for controls. Agricultural pesticides were categorized a priori into groups based on similarities in toxicological effects, physicochemical properties, and target pests or uses. The effects of moderate and high exposure for each group of pesticides were estimated using conditional logistic regression. Elevated ALL risk was associated with lifetime moderate exposure, but not high exposure, to certain physicochemical categories of pesticides, including organophosphates, chlorinated phenols, and triazines, and with pesticides classified as insecticides or fumigants. A similar pattern was also observed for several toxicological groups of pesticides. These findings suggest future directions for the identification of specific pesticides that may play a role in the etiology of childhood leukemia.

Indexed as

CaliforniaCase-Control StudiesChildChild, PreschoolEnvironmental ExposureFemaleHumansLogistic ModelsMalePesticidesPrecursor Cell Lymphoblastic Leukemia-LymphomaPesticides

Identifiers

PMID19700145
PMCPMC2748130
OpenAlexW2028657932

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.