ArticleNeurotoxicology and teratology
Prenatal cocaine exposure alters emotional arousal regulation and its effects on working memory.
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Emotional Dysregulation in Children and Adolescents With Psychiatric Disorders. A Narrative Review.Frontiers in psychiatry · 2021Pooled it
- The impact of affective information on working memory: A pair of meta-analytic reviews of behavioral and neuroimaging evidence.Psychological bulletin · 2019Pooled it
- Pooled it
- Article
- Functional dissection of prenatal drug effects on baby brain and behavioral development.Human brain mapping · 2020Article
- Fifty Years of Research on Prenatal Substances: Lessons Learned for the Opioid Epidemic.Adversity and resilience science · 2020Article
- Longitudinal changes of amygdala functional connectivity in adolescents prenatally exposed to cocaine.Drug and alcohol dependence · 2019Article
- Parental Substance Abuse As an Early Traumatic Event. Preliminary Findings on Neuropsychological and Personality Functioning in Young Drug Addicts Exposed to Drugs Early.Frontiers in psychology · 2016Article
- Executive function and cortical thickness in youths prenatally exposed to cocaine, alcohol and tobacco.Developmental cognitive neuroscience · 2015Article
- Prenatal substance exposure and child self-regulation: Pathways to risk and protection.Journal of experimental child psychology · 2015Article
- Prenatal drug exposure affects neonatal brain functional connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Prenatal cocaine effects on brain structure in early infancy.NeuroImage · 2014Article
- Prenatal cocaine exposure and adolescent neural responses to appetitive and stressful stimuli.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Connectomics signatures of prenatal cocaine exposure affected adolescent brains.Human brain mapping · 2013Article
- Prenatal cocaine exposure alters functional activation in the ventral prefrontal cortex and its structural connectivity with the amygdala.Psychiatry research · 2013Article
- Adolescents with prenatal cocaine exposure show subtle alterations in striatal surface morphology and frontal cortical volumes.Journal of neurodevelopmental disorders · 2012Article
- Memory ability and hippocampal volume in adolescents with prenatal drug exposure.Neurotoxicology and teratology · 2012Article
- Neonatal methylphenidate does not impair adult spatial learning in the Morris water maze in rats.Neuroscience letters · 2011Article
- Prenatal Cocaine Disrupts Serotonin Signaling-Dependent Behaviors: Implications for Sex Differences, Early Stress and Prenatal SSRI Exposure.Current neuropharmacology · 2011Article
- Increased "default mode" activity in adolescents prenatally exposed to cocaine.Human brain mapping · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
While prenatal cocaine exposure (PCE) has been associated with arousal dysregulation and attentional impairments in both human and animal studies, the neurobiological bases of these teratogenic effects have not been well characterized. In the current study, we report functional neuroimaging observations of these effects in exposed youth. Using functional magnetic resonance imaging (fMRI), we embedded task-irrelevant emotional distracters in a working memory task to examine the interaction of emotional arousal and memory in 33 PCE and 23 non-exposed adolescents. Though with similar behavioral performance, the two groups exhibited different activation patterns associated with emotion-memory interactions. On the one hand, higher memory load attenuated emotion-related amygdala activation in controls but not in the exposed adolescents; on the other hand, prefrontal activation associated with memory load decreased in the presence of emotional distraction in the controls but increased in the exposed group. These group interaction differences suggest neurobiological substrates for arousal-associated neuronal alterations related to prenatal cocaine exposure. Consistent with previous findings in behavioral and physiological studies, the present neuroimaging data provided more in-depth evidence supporting the view that PCE has significant long-term teratogenic effect on arousal regulation system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.