ArticleThe American journal of medicine2009
Psychiatric comorbidity and other psychological factors in patients with "chronic Lyme disease".
Article in The American journal of medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Guidelines for diagnosis and treatment in neurology - Lyme neuroborreliosis.German medical science : GMS e-journal · 2025Guideline
- Guidelines for diagnosis and treatment in neurology - Lyme neuroborreliosis.German medical science : GMS e-journal · 2020Guideline
- A systematic review of Borrelia burgdorferi morphologic variants does not support a role in chronic Lyme disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Pooled it
- Persistent self-reported health complaints in Norwegians who attribute their symptoms to tick bites or tick-borne disease- a cross-sectional controlled study.BMC infectious diseases · 2025Article
- Residual Symptoms and Quality of Life After Treated Lyme Neuroborreliosis: Case-Control Study (QoLYME).Open forum infectious diseases · 2025Article
- Neuropsychiatric Manifestations of Lyme Disease: A Literature Review of Psychiatric and Cognitive Impacts.Acta medica Lituanic · 2025Article
- SSRI use during acute COVID-19 and risk of long COVID among patients with depression.BMC medicine · 2024Observational
- Somatization in Polypharmacy: Hiding in Plain Sight.Innovations in pharmacy · 2024Article
- Determinants of persistent symptoms after treatment for Lyme borreliosis: a prospective observational cohort study.EBioMedicine · 2023Observational
- Long COVID as a functional somatic symptom disorder caused by abnormally precise prior expectations during Bayesian perceptual processing: A new hypothesis and implications for pandemic response.SAGE open medicine · 2023Review
- Evaluation of a Novel Multiplex High-Definition PCR Assay for Detection of Tick-Borne Pathogens in Whole-Blood Specimens.Journal of clinical microbiology · 2019Article
- Observational
- Changes in Anxiety and Depression Are Mediated by Changes in Pain Severity in Patients Undergoing Lower-Extremity Total Joint Arthroplasty.Regional anesthesia and pain medicine · 2018Article
- Lyme borreliosis.Nature reviews. Disease primers · 2016Review
- Characterizing "fibrofog": Subjective appraisal, objective performance, and task-related brain activity during a working memory task.NeuroImage. Clinical · 2016Article
- Application of Nanotrap technology for high sensitivity measurement of urinary outer surface protein A carboxyl-terminus domain in early stage Lyme borreliosis.Journal of translational medicine · 2015Article
- Lyme neuroborreliosis-epidemiology, diagnosis and management.Nature reviews. Neurology · 2015Review
- Unorthodox alternative therapies marketed to treat Lyme disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Review
- Chronic Lyme disease.Infectious disease clinics of North America · 2015Review
- New-onset panic, depression with suicidal thoughts, and somatic symptoms in a patient with a history of lyme disease.Case reports in psychiatry · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThere is no evidence of current or previous Borrelia burgdorferi infection in most patients evaluated at university-based Lyme disease referral centers. Instead, psychological factors likely exacerbate the persistent diffuse symptoms or "Chronic Multisymptom Illness" (CMI) incorrectly ascribed to an ongoing chronic infection with B. burgdorferi. The objective of this study was to assess the medical and psychiatric status of such patients and compare these findings to those from patients without CMI.
methodsThere were 240 consecutive patients who underwent medical evaluation and were screened for clinical disorders (eg, depression and anxiety) with diagnoses confirmed by structured clinical interviews at an academic Lyme disease referral center in New Jersey. Personality disorders, catastrophizing, and negative and positive affect also were evaluated, and all factors were compared between groups and with functional outcomes.
resultsOf our sample, 60.4% had symptoms that could not be explained by current Lyme disease or another medical condition other than CMI. After adjusting for age and sex, clinical disorders were more common in CMI than in the comparison group (P <.001, odds ratio 3.54, 95% confidence interval, 1.97-6.55), but personality disorders were not significantly more common. CMI patients had higher negative affect, lower positive affect, and a greater tendency to catastrophize pain (P <.001) than did the comparison group. Except for personality disorders, all psychological factors were related to worse functioning. Our explanatory model based on these factors was confirmed.
conclusionsPsychiatric comorbidity and other psychological factors are prominent in the presentation and outcome of some patients who inaccurately ascribe longstanding symptoms to "chronic Lyme disease."
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.