ReviewBrain, behavior, and immunity2010
Stress-related modulation of inflammation in experimental models of bowel disease and post-infectious irritable bowel syndrome: role of corticotropin-releasing factor receptors.
Review in Brain, behavior, and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 102 citations in OpenAlex.
- Stressor- and Tissue-Specific Regulation of the Corticotropin-Releasing Factor System Across Epithelial Tissues in Rainbow Trout.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- [The Relationship of Dysbiosis of Duodenal Microbiome and Functional Dyspepsia].The Korean journal of helicobacter and upper gastrointestinal research · 2024Review
- From gut to brain: understanding the role of microbiota in inflammatory bowel disease.Frontiers in immunology · 2024Review
- Correlation of mental and psychological status with disease activity in patients with inflammatory bowel disease using SCL-90 R Questionnaire.Przeglad gastroenterologiczny · 2024Article
- Role of the duodenal microbiota in functional dyspepsia.Neurogastroenterology and motility · 2022Review
- Modulation of Intestinal Corticotropin-Releasing Hormone Signaling by the Herbal Preparation STW 5-II: Possible Mechanisms for Irritable Bowel Syndrome Management.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Review
- Brain-gut-liver axis: Chronic psychological stress promotes liver injury and fibrosisFrontiers in cellular and infection microbiology · 2022Article
- Circulating Pro-inflammatory Cytokines Do Not Explain Interindividual Variability in Visceral Sensitivity in Healthy Individuals.Frontiers in neuroscience · 2022Article
- A Review of Inflammatory Bowel Disease: A Model of Microbial, Immune and Neuropsychological Integration.Public health reviews · 2021Review
- Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk.Journal of clinical medicine · 2019Review
- Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified.World journal of gastroenterology · 2019Review
- The Costs of Living Together: Immune Responses to the Microbiota and Chronic Gut Inflammation.Applied and environmental microbiology · 2019Review
- Defining Early Life Stress as a Precursor for Autoimmune Disease.Critical reviews in immunology · 2019Review
- Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract.Current molecular pharmacology · 2018Review
- Involvement of Corticotropin-Releasing Factor and Receptors in Immune Cells in Irritable Bowel Syndrome.Frontiers in endocrinology · 2018Review
- Post-Infectious Irritable Bowel Syndrome.Current gastroenterology reports · 2017Review
- Corticotropin-releasing factor stimulates colonic motilityWorld journal of gastroenterology · 2017Article
- The Impact of Microbiota-Gut-Brain Axis on Diabetic Cognition Impairment.Frontiers in aging neuroscience · 2017Review
- Corticotropin-releasing hormone receptor 1 (CRH-R1) polymorphisms are associated with irritable bowel syndrome and acoustic startle response.Psychoneuroendocrinology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The interaction between gut inflammatory processes and stress is gaining increasing recognition. Corticotropin-releasing factor (CRF)-receptor activation in the brain is well established as a key signaling pathway initiating the various components of the stress response including in the viscera. In addition, a local CRF signaling system has been recently established in the gut. This review summarize the present knowledge on mechanisms through which both brain and gut CRF receptors modulate intestinal inflammatory processes and its relevance towards increased inflammatory bowel disease (IBD) activity and post-infectious irritable bowel syndrome (IBS) susceptibility induced by stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.