ArticleThe Journal of infectious diseases2009
Potential antifungal effects of human platelets against zygomycetes in vitro.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- The Unnoticed Threat: Clinical Characteristics, Risk Factors, and Outcome of Mucormycosis in Solid Organ Transplantation.Journal of fungi (Basel, Switzerland) · 2025Review
- Complement, but Not Platelets, Plays a Pivotal Role in the Outcome of Mucormycosis In Vivo.Journal of fungi (Basel, Switzerland) · 2023Article
- Mucormycosis and COVID-19-Associated Mucormycosis: Insights of a Deadly but Neglected Mycosis.Journal of fungi (Basel, Switzerland) · 2022Review
- Article
- New insights on mucormycosis and its association with the COVID-19 pandemic.Future science OA · 2022Review
- Pathogenesis and Pathology of COVID-Associated Mucormycosis: What Is New and Why.Current fungal infection reports · 2022Review
- COVID19 associated mucormycosis: Is GRP78 a possible link?Journal of infection and public health · 2021Review
- Mucormycosis in Indian COVID-19 Patients: Insight into Its Patho-Genesis, Clinical Manifestation, and Management Strategies.Antibiotics (Basel, Switzerland) · 2021Review
- Dysregulation of Key Proteinases inReports of biochemistry & molecular biology · 2021Article
- Mucormycosis Amid COVID-19 Crisis: Pathogenesis, Diagnosis, and Novel Treatment Strategies to Combat the Spread.Frontiers in microbiology · 2021Review
- Mucorales Species and Macrophages.Journal of fungi (Basel, Switzerland) · 2020Review
- Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors.Medical mycology · 2019Review
- Candida: Platelet Interaction and Platelet Activity in vitro.Journal of innate immunity · 2019Article
- The mucormycete-host interface.Current opinion in microbiology · 2017Review
- Innate and Adaptive Immunity to Mucorales.Journal of fungi (Basel, Switzerland) · 2017Review
- Interaction of platelets and anidulafungin against Aspergillus fumigatus.Antimicrobial agents and chemotherapy · 2013Article
- [Pathophysiology and biochemistry of platelets].Der Internist · 2010Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Zygomycosis is increasingly recognized in immunocompromised hosts. We investigated whether platelets become activated after contact with Zygomycetes and adhere to conidial and hyphal structures using immunofluorescence. The platelets' influence on fungal viability was evaluated by assessing hyphal elongation and hyphal damage. Platelets became activated and strongly adhered to conidia and hyphae of Zygomycetes. Platelets induced time dependent damage to hyphae and significantly reduced (P<.05) hyphal elongation. We found that platelets possess antifungal capacities against Zygomycetes based on granule dependent mechanisms and significantly reduce fungal growth and spread, both of which are of major importance in evolving invasive disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.