Evidence map›Paper›PMID 19698068›Full record

ReviewTissue engineering. Part B, Reviews2010

Challenges in cardiac tissue engineering.

Gordana Vunjak-Novakovic, Nina Tandon, Amandine Godier, Robert Maidhof, Anna Marsano, Timothy P Martens, Milica Radisic

Abstract readEvaluation StudyReview
In one paragraph

Review in Tissue engineering. Part B, Reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers.

0numbers the graph read from it
0cells of the map it votes in
181citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

181 citing papers in PubMed.

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121 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gordana Vunjak-NovakovicDepartment of Biomedical Engineering, Columbia University, New York, New York 10032, USA.
Nina Tandon
Amandine Godier
Robert Maidhof
Anna Marsano
Timothy P Martens
Milica Radisic

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Engineering Vascularized Cardiac MuscleR01HL076485 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Gordana Vunjak-Novakovic · 2005 to 2026
$9.2M
Multidisciplinary Training in Translational Cardiovascular ResearchT32HL087745 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2007 to 2011
$1.8M
Controlled gene delivery for in vivo vascularization of an engineered cardiac patR21HL089913 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI VUNJAK-NOVAKOVIC, GORDANA · 2008 to 2009
$403k
NHLBI NIH HHS R01 HL076485NHLBI NIH HHS R21 HL089913NHLBI NIH HHS T 32 HL087745NIBIB NIH HHS P41 EB002520NIBIB NIH HHS P41-EB002520
6 · The paper itself

Abstract

Cardiac tissue engineering aims to create functional tissue constructs that can reestablish the structure and function of injured myocardium. Engineered constructs can also serve as high-fidelity models for studies of cardiac development and disease. In a general case, the biological potential of the cell-the actual "tissue engineer"-is mobilized by providing highly controllable three-dimensional environments that can mediate cell differentiation and functional assembly. For cardiac regeneration, some of the key requirements that need to be met are the selection of a human cell source, establishment of cardiac tissue matrix, electromechanical cell coupling, robust and stable contractile function, and functional vascularization. We review here the potential and challenges of cardiac tissue engineering for developing therapies that could prevent or reverse heart failure.

Indexed as

AnimalsElectric StimulationHeartHeart TransplantationHumansModels, BiologicalMyocardiumOrgan Culture TechniquesPerfusionTissue Engineering

Identifiers

PMID19698068
PMCPMC2946883

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.