ArticleThe EMBO journal1990
The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-1.4 gene.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed, 189 citations in OpenAlex.
- Potential Alzheimer's early biomarkers in a transgenic rat model and benefits of diazoxide/dibenzoylmethane co-treatment on spatial memory and AD-pathology.Scientific reports · 2024Article
- Identification of a neural development gene expression signature in colon cancer stem cells reveals a role foriScience · 2022Article
- Cooperation, cis-interactions, versatility and evolutionary plasticity of multiple cis-acting elements underlie krox20 hindbrain regulation.PLoS genetics · 2018Article
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- Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behavior.Pharmacology, biochemistry, and behavior · 2008Article
- Distinct functions of egr gene family members in cognitive processes.Frontiers in neuroscience · 2008Article
- Rational design of memory in eukaryotic cells.Genes & development · 2007Article
- Progesterone derivatives increase expression of Krox-20 and Sox-10 in rat Schwann cells.Journal of molecular neuroscience : MN · 2007Article
- Paradoxical role of an Egr transcription factor family member, Egr2/Krox20, in learning and memory.Frontiers in behavioral neuroscience · 2007Article
- Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain.The EMBO journal · 2002Article
- The Drosophila nuclear lamina protein YA binds to DNA and histone H2B with four domains.Molecular biology of the cell · 2002Article
- A distal upstream enhancer from the myelin basic protein gene regulates expression in myelin-forming schwann cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Two distinct domains in Staf to selectively activate small nuclear RNA-type and mRNA promoters.Molecular and cellular biology · 1998Article
- Functional dissection of YA, an essential, developmentally regulated nuclear lamina protein in Drosophila melanogaster.Molecular and cellular biology · 1998Article
- Cloning and characterization of the mouse vitamin D receptor promoter.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Staf, a promiscuous activator for enhanced transcription by RNA polymerases II and III.The EMBO journal · 1997Article
- Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site.The EMBO journal · 1996Article
- Staf, a novel zinc finger protein that activates the RNA polymerase III promoter of the selenocysteine tRNA gene.The EMBO journal · 1995Article
- Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Krox-20 is a mouse zinc finger gene expressed in a segment-specific manner in the early central nervous system, which makes it a potential developmental control gene. In this report, we show that the Krox-20 protein binds in vitro to two specific DNA sites located upstream from the homeobox containing gene Hox-1.4. The nucleotide sequence recognized by Krox-20 is closely related to the Sp1 target sequence, which is consistent with the similarity existing between the zinc fingers of the two proteins. In co-transfection experiments in cultured cells, Krox-20 dramatically activates transcription from the herpes simplex virus thymidine kinase promoter when an oligomer of its binding site is present in cis close to the promoter. Analysis of mutated binding sites demonstrates that the level of activation by Krox-20 correlates with the affinity of the protein for the mutant sequence. These data indicate that Krox-20 constitutes a sequence-specific DNA-binding transcription factor. Parallel analysis of the expression of Krox-20 and Hox-1.4 in the neural tube by in situ hybridization revealed no overlap, arguing against direct interactions between these two genes. The possible involvement of Krox-20 in the regulation of the transcription of other homeobox genes is discussed in view of their respective patterns of expression.
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