ReviewMuscle & nerve2010
RNA processing defects associated with diseases of the motor neuron.
Review in Muscle & nerve, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Candidate proteins, metabolites and transcripts in the Biomarkers for Spinal Muscular Atrophy (BforSMA) clinical study.PloS one · 2012Trial
- The tRNA regulome in neurodevelopmental and neuropsychiatric disease.Molecular psychiatry · 2022Review
- Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.Human molecular genetics · 2016Article
- Gem depletion: amyotrophic lateral sclerosis and spinal muscular atrophy crossover.CNS neuroscience & therapeutics · 2014Review
- EXOSC3 mutations in isolated cerebellar hypoplasia and spinal anterior horn involvement.Journal of neurology · 2013Article
- Spinal muscular atrophy and the antiapoptotic role of survival of motor neuron (SMN) protein.Molecular neurobiology · 2013Review
- The Gemin associates of survival motor neuron are required for motor function in Drosophila.PloS one · 2013Article
- Identification of cytoplasmic capping targets reveals a role for cap homeostasis in translation and mRNA stability.Cell reports · 2012Article
- Spliceosomal small nuclear ribonucleoprotein biogenesis defects and motor neuron selectivity in spinal muscular atrophy.Brain research · 2012Review
- Common pathways of autoimmune inflammatory myopathies and genetic neuromuscular disorders.Clinical reviews in allergy & immunology · 2012Review
- Microarray analysis of peripheral blood lymphocytes from ALS patients and the SAFE detection of the KEGG ALS pathway.BMC medical genomics · 2011Article
- Spinal muscular atrophy: a timely review.Archives of neurology · 2011Article
- Classification, diagnosis and potential mechanisms in pontocerebellar hypoplasia.Orphanet journal of rare diseases · 2011Review
- Senataxin mutations and amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases · 2011Article
- The RNA helicase database.Nucleic acids research · 2011Article
- Lack of effect of methylene blue in the SOD1 G93A mouse model of amyotrophic lateral sclerosis.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Rapid progress in the discovery of motor neuron disease genes in amyotrophic lateral sclerosis, the spinal muscular atrophies, hereditary motor neuropathies, and lethal congenital contracture syndromes is providing new perspectives and insights into the molecular pathogenesis of the motor neuron. Motor neuron disease genes are often expressed throughout the body with essential functions in all cells. A survey of these functions indicates that motor neurons are uniquely sensitive to perturbations in RNA processing pathways dependent on the interaction of specific RNAs with specific RNA-binding proteins, which presumably result in aberrant formation and function of ribonucleoprotein complexes. This review provides a summary of currently recognized RNA processing defects linked to human motor neuron diseases.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.