ArticleVirchows Archiv : an international journal of pathology2009
High resolution analysis of DNA copy-number aberrations of chromosomes 8, 13, and 20 in gastric cancers.
Article in Virchows Archiv : an international journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 58 citations in OpenAlex.
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- Acinar cell carcinomas of the pancreas: a molecular analysis in a series of 57 cases.Virchows Archiv : an international journal of pathology · 2014Article
- Pathogenetic mechanisms in gastric cancer.World journal of gastroenterology · 2014Review
- Genetic alterations of chromosome 8 genes in oral cancer.Scientific reports · 2014Article
- Chromosome 8q as the most frequent target for amplification in early gastric carcinoma.Oncology letters · 2014Article
- High-level copy number gains of established and potential drug target genes in gastric cancer as a lead for treatment development and selection.Cellular oncology (Dordrecht, Netherlands) · 2014Article
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- Copy number alterations in small intestinal neuroendocrine tumors determined by array comparative genomic hybridization.BMC cancer · 2013Article
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- PTP1B expression contributes to gastric cancer progression.Medical oncology (Northwood, London, England) · 2012Article
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- Frequent gene amplification predicts poor prognosis in gastric cancer.International journal of molecular sciences · 2012Article
- Losses of chromosome 5q and 14q are associated with favorable clinical outcome of patients with gastric cancer.The oncologist · 2012Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA copy-number gains of chromosomes 8q, 13q, and 20q are frequently observed in gastric cancers. Moreover gain of chromosome 20q has been associated with lymph node metastasis. The aim of this study was to correlate DNA copy-number changes of individual genes on chromosomes 8q, 13q, and 20q in gastric adenocarcinomas to clinicopathological data. DNA isolated from 63 formalin-fixed and paraffin-embedded gastric adenocarcinoma tissue samples was analyzed by whole-genome microarray comparative genomic hybridization and by multiplex ligation-dependent probe amplification (MLPA), targeting 58 individual genes on chromosomes 8, 13, and 20. Using array comparative genomic hybridization, gains on 8q, 13q, and 20q were observed in 49 (77.8%), 25 (39.7%), and 49 (77.8%) gastric adenocarcinomas, respectively. Gain of chromosome 20q was significantly correlated with lymph node metastases (p = 0.05) and histological type (p = 0.02). MLPA revealed several genes to be frequently gained in DNA copy number. The oncogene c-myc on 8q was gained in 73% of the cancers, while FOXO1A and ATP7B on 13q were both gained in 28.6% of the cases. Multiple genes on chromosome 20q showed gains in more than 60% of the cancers. DNA copy-number gains of TNFRSF6B (20q13.3) and ZNF217 (20q13.2) were significantly associated with lymph node metastasis (p = 0.02) and histological type (p = 0.02), respectively. In summary, gains of chromosomes 8q, 13q, and 20q in gastric adenocarcinomas harbor DNA copy-number gains of known and putative oncogenes. ZNF217 and TNFRSF6B are associated with important clinicopathological variables, including lymph node status.
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