ArticlePLoS computational biology2009
Can molecular motors drive distance measurements in injured neurons?
Article in PLoS computational biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Peripheral Nerve Transection Predominantly Drives Sympathetic Nerve Sprouting in Mouse Dorsal Root Ganglia.bioRxiv : the preprint server for biology · 2025Article
- Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell.The Journal of physiology · 2025Article
- High-resolution mapping of injury-site dependent functional recovery in a single axon in zebrafish.Communications biology · 2020Article
- Article
- Delayed feedback model of axonal length sensing.Biophysical journal · 2015Article
- Axonal transport cargo motor count versus average transport velocity: is fast versus slow transport really single versus multiple motor transport?Journal of theoretical biology · 2015Article
- A frequency-dependent decoding mechanism for axonal length sensing.Frontiers in cellular neuroscience · 2015Article
- Can a death signal half-life be used to sense the distance to a lesion site in axons?Journal of biological physics · 2015Article
- Axon-soma communication in neuronal injury.Nature reviews. Neuroscience · 2014Review
- A motor-driven mechanism for cell-length sensing.Cell reports · 2012Article
- Cargo distributions differentiate pathological axonal transport impairments.Journal of theoretical biology · 2012Article
- Axonal transcription factors signal retrogradely in lesioned peripheral nerve.The EMBO journal · 2012Article
- From synapse to nucleus and back again--communication over distance within neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins.Nature reviews. Microbiology · 2010Review
- Signaling to transcription networks in the neuronal retrograde injury response.Science signaling · 2010Article
- Neuroproteomics approaches to decipher neuronal regeneration and degeneration.Molecular & cellular proteomics : MCP · 2010Review
- The complexity of living: when biology meets theory. Conference on Systems Dynamics of Intracellular Communication.EMBO reports · 2009Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injury to nerve axons induces diverse responses in neuronal cell bodies, some of which are influenced by the distance from the site of injury. This suggests that neurons have the capacity to estimate the distance of the injury site from their cell body. Recent work has shown that the molecular motor dynein transports importin-mediated retrograde signaling complexes from axonal lesion sites to cell bodies, raising the question whether dynein-based mechanisms enable axonal distance estimations in injured neurons? We used computer simulations to examine mechanisms that may provide nerve cells with dynein-dependent distance assessment capabilities. A multiple-signals model was postulated based on the time delay between the arrival of two or more signals produced at the site of injury-a rapid signal carried by action potentials or similar mechanisms and slower signals carried by dynein. The time delay between the arrivals of these two types of signals should reflect the distance traversed, and simulations of this model show that it can indeed provide a basis for distance measurements in the context of nerve injuries. The analyses indicate that the suggested mechanism can allow nerve cells to discriminate between distances differing by 10% or more of their total axon length, and suggest that dynein-based retrograde signaling in neurons can be utilized for this purpose over different scales of nerves and organisms. Moreover, such a mechanism might also function in synapse to nucleus signaling in uninjured neurons. This could potentially allow a neuron to dynamically sense the relative lengths of its processes on an ongoing basis, enabling appropriate metabolic output from cell body to processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.