Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2009
Influence of hormone replacement therapy on eccentric exercise induced myogenic gene expression in postmenopausal women.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Menstrual cycle hormones and oral contraceptives: a multimethod systems physiology-based review of their impact on key aspects of female physiology.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Pooled it
- Pooled it
- Myofibrillar Protein Synthesis Rates Do not Differ With Low and High Estradiol Concentrations Across the Menstrual Cycle.The Journal of clinical endocrinology and metabolism · 2026Trial
- Trial
- Effect of Periodized Resistance Training on Skeletal Muscle During Androgen Deprivation Therapy for Prostate Cancer: A Pilot Randomized Trial.Integrative cancer therapiesTrial
- Sex hormones and menopause hormone therapy predict muscle strength across the lifespan.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- How Acute and Chronic Exercise Regulate Muscle Atrophic Genes to Mitigate Sarcopenia: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2026Review
- Menopause, Female Sex Hormones, Skeletal Muscle Mass and Muscle Protein Turnover in Humans.Journal of cachexia, sarcopenia and muscle · 2026Review
- Muscle weakness after critical illness: unravelling biological mechanisms and clinical hurdles.Critical care (London, England) · 2025Review
- Postexercise myofibrillar protein synthesis rates do not differ following 1.5 g essential amino acids compared with 15 and 20 g of whey protein in young females.American journal of physiology. Endocrinology and metabolism · 2025Article
- Transcriptomic Profiling Reveals 17β-Estradiol Treatment Represses Ubiquitin-Proteasomal Mediators in Skeletal Muscle of Ovariectomized Mice.Journal of cachexia, sarcopenia and muscle · 2025Article
- Hormones, Hypertrophy, and Hype: An Evidence-Guided Primer on Endogenous Endocrine Influences on Exercise-Induced Muscle Hypertrophy.Exercise and sport sciences reviews · 2024Review
- Sexual dimorphisms in skeletal muscle: current concepts and research horizons.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Review
- Polysaccharide of Atractylodes macrocephala Koidz alleviates LPS-induced proliferation, differentiation inhibition and excessive apoptosis in chicken embryonic myogenic cells.Veterinary medicine and science · 2024Article
- Sex hormones and physical function among the Chinese oldest-old and centenarian women.Journal of translational medicine · 2022Article
- Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men.GeroScience · 2022Article
- Role of exercise in estrogen deficiency-induced sarcopenia.Journal of exercise rehabilitation · 2022Review
- The non-modifiable factors age, gender, and genetics influence resistance exercise.Frontiers in aging · 2022Review
- Sex Hormones and Satellite Cell Regulation in Women.Translational sports medicine · 2022Review
- Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Hormone replacement therapy (HRT) is used in postmenopausal women to relieve symptoms of menopause and prevent osteoporosis. We sought to evaluate changes in mRNA expression of key myogenic factors in postmenopausal women taking and not taking HRT following a high-intensity eccentric resistance exercise. Fourteen postmenopausal women were studied and included 6 control women not using HRT (59 +/- 4 years, 63 +/- 17 kg) and 8 women using traditional HRT (59 +/- 4 yr, 89 +/- 24 kg). Both groups performed 10 sets of 10 maximal eccentric repetitions of single-leg extension on a Cybex dynamometer at 60 degrees /s. Muscle biopsies of the vastus lateralis were obtained from the exercised leg at baseline and 4 h after the exercise bout. Gene expression was determined using RT-PCR for follistatin, forkhead box 3A (FOXO3A), muscle atrophy F-box (MAFbx), muscle ring finger-1 (MuRF-1), myogenic differentiation factor (MyoD), myogenin, myostatin, myogenic factor 5 (Myf5), and muscle regulatory factor 4 (MRF4). At rest, the HRT group expressed higher levels of MyoD, myogenin, Myf5, MRF4, and follistatin (P < 0.05). In response to eccentric exercise, follistatin, MyoD, myogenin, Myf5, and MRF4 were significantly increased (P <or= 0.05) and FOXO3A, MAFbx, MuRF-1, and myostatin were significantly decreased in the control and HRT groups (P <or= 0.05). Significantly greater changes in mRNA expression of follistatin, FOXO3A, MAFbx, MuRF-1, MyoD, myogenin, myostatin, Myf5, and MRF4 (p<or=0.05) occurred in the HRT group than in the control group after exercise. These data suggest that postmenopausal women using HRT express higher myogenic regulatory factor gene expression, which may reflect an attempt to preserve muscle mass. Furthermore, postmenopausal women using HRT experienced a greater myogenic response to maximal eccentric exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.