ArticleHuman molecular genetics2009
Transplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility.
Article in Human molecular genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed.
- Derivation of oocyte-like cells from putative embryonic stem cells and parthenogenetically activated into blastocysts in goat.Scientific reports · 2020Article
- Synergistic effect of Huyang Yangkun Formula and embryonic stem cells on 4-vinylcyclohexene diepoxide induced premature ovarian insufficiency in mice.Chinese medicine · 2020Article
- Female Fertility Preservation through Stem Cell-based Ovarian Tissue Reconstitution In Vitro and Ovarian Regeneration In Vivo.Clinical medicine insights. Reproductive health · 2019Review
- Complete in vitro oogenesis: retrospects and prospects.Cell death and differentiation · 2017Review
- Ovarian regeneration: The potential for stem cell contribution in the postnatal ovary to sustained endocrine function.Molecular and cellular endocrinology · 2017Review
- A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways.Scientific reports · 2016Article
- In vitro differentiation of germ cells from stem cells: a comparison between primordial germ cells and in vitro derived primordial germ cell-like cells.Cell death & disease · 2015Review
- Artificial gametes from stem cells.Clinical and experimental reproductive medicine · 2015Review
- Postnatal oogenesis in humans: a review of recent findings.Stem cells and cloning : advances and applications · 2015Review
- Human iPS Cell-Derived Germ Cells: Current Status and Clinical Potential.Journal of clinical medicine · 2014Review
- Characterization of embryonic stem-like cells derived from HEK293T cells through miR302/367 expression and their potentiality to differentiate into germ-like cells.Cytotechnology · 2014Article
- Human germ cell formation in xenotransplants of induced pluripotent stem cells carrying X chromosome aneuploidies.Scientific reports · 2014Article
- Fate of induced pluripotent stem cells following transplantation to murine seminiferous tubules.Human molecular genetics · 2014Article
- Fate of iPSCs derived from azoospermic and fertile men following xenotransplantation to murine seminiferous tubules.Cell reports · 2014Article
- The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.Current genomics · 2014Article
- Induced pluripotent stem cell potential in medicine, specifically focused on reproductive medicine.Frontiers in surgery · 2014Review
- Cell therapy for chemically induced ovarian failure in mice.Stem cells international · 2014Article
- Location and characterization of female germline stem cells (FGSCs) in juvenile porcine ovary.Cell proliferation · 2013Article
- A comparison of the multiple oocyte maturation gene expression patterns between the newborn and adult mouse ovary.Iranian journal of reproductive medicine · 2013Article
- Human amniotic fluid stem cells have a potential to recover ovarian function in mice with chemotherapy-induced sterility.BMC developmental biology · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Ten to 15% of couples are infertile, with the most common causes being linked to the production of few or no oocytes or sperm. Yet, our understanding of human germ cell development is poor, at least in part due to the inaccessibility of early stages to genetic and developmental studies. Embryonic stem cells (ESCs) provide an in vitro system to study oocyte development and potentially treat female infertility. However, most studies of ESC differentiation to oocytes have not documented fundamental properties of endogenous development, making it difficult to determine the physiologic relevance of differentiated germ cells. Here, we sought to establish fundamental parameters of oocyte development during ESC differentiation to explore suitability for basic developmental genetic applications using the mouse as a model prior to translating to the human system. We demonstrate a timeline of definitive germ cell differentiation from ESCs in vitro that initially parallels endogenous oocyte development in vivo by single-cell expression profiling and analysis of functional milestones including responsiveness to defined maturation media, shared genetic requirement of Dazl, and entry into meiosis. However, ESC-derived oocyte maturation ultimately fails in vitro. To overcome this obstacle, we transplant ESC-derived oocytes into an ovarian niche to direct their functional maturation and, thereby, present rigorous evidence of oocyte physiologic relevance and a potential therapeutic strategy for infertility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.