ArticleThe Journal of biological chemistry2009
CD38/cADPR/Ca2+ pathway promotes cell proliferation and delays nerve growth factor-induced differentiation in PC12 cells.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- CD38 promotes hematopoietic stem cell dormancy.PLoS biology · 2024Article
- Article
- NAADP Receptors.Cold Spring Harbor perspectives in biology · 2019Review
- Review
- Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia-reoxygenation triggering NAD(P)H depletion.American journal of physiology. Cell physiology · 2018Article
- Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of MnScientific reports · 2018Article
- CD38 promotes angiotensin II-induced cardiac hypertrophy.Journal of cellular and molecular medicine · 2017Article
- Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake.Biological trace element research · 2017Article
- Implication of CD38 gene in autophagic degradation of collagen I in mouse coronary arterial myocytes.Frontiers in bioscience (Landmark edition) · 2017Article
- Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca(2+) signaling pathway.World journal of biological chemistry · 2014Review
- Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.The Journal of biological chemistry · 2013Article
- Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells.PloS one · 2013Article
- Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway.The Journal of biological chemistry · 2012Article
- Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization.The Journal of biological chemistry · 2012Review
- A novel fluorescent cell membrane-permeable caged cyclic ADP-ribose analogue.The Journal of biological chemistry · 2012Article
- Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).PloS one · 2012Article
- A cell permeable NPE caged ADP-ribose for studying TRPM2.PloS one · 2012Article
- Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta.PloS one · 2012Article
- Cyclic ADP ribose is a novel regulator of intracellular Ca2+ oscillations in human bone marrow mesenchymal stem cells.Journal of cellular and molecular medicine · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular Ca(2+) mobilization plays an important role in a wide variety of cellular processes, and multiple second messengers are responsible for mediating intracellular Ca(2+) changes. Here we explored the role of one endogenous Ca(2+)-mobilizing nucleotide, cyclic adenosine diphosphoribose (cADPR), in the proliferation and differentiation of neurosecretory PC12 cells. We found that cADPR induced Ca(2+) release in PC12 cells and that CD38 is the main ADP-ribosyl cyclase responsible for the acetylcholine (ACh)-induced cADPR production in PC12 cells. In addition, the CD38/cADPR signaling pathway is shown to be required for the ACh-induced Ca(2+) increase and cell proliferation. Inhibition of the pathway, on the other hand, accelerated nerve growth factor (NGF)-induced neuronal differentiation in PC12 cells. Conversely, overexpression of CD38 increased cell proliferation but delayed NGF-induced differentiation. Our data indicate that cADPR plays a dichotomic role in regulating proliferation and neuronal differentiation of PC12 cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.