ArticleVeterinary immunology and immunopathology2010
Variant-specific and diminishing immune responses towards the highly variable MSP2(P44) outer membrane protein of Anaplasma phagocytophilum during persistent infection in lambs.
Article in Veterinary immunology and immunopathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Generation of Population-Level Diversity inPathogens (Basel, Switzerland) · 2025Article
- Comparative Whole Genome Analysis of anPathogens (Basel, Switzerland) · 2022Article
- Genome variation in tick infestation and cryptic divergence in Tunisian indigenous sheep.BMC genomics · 2022Article
- Epidemiological and Clinicopathological Features ofFrontiers in veterinary science · 2021Review
- ExperimentalFrontiers in veterinary science · 2020Article
- A lifelong study of a pack Rhodesian ridgeback dogs reveals subclinical and clinical tick-borne Anaplasma phagocytophilum infections with possible reinfection or persistence.Parasites & vectors · 2018Article
- Intrauterine Transmission of Anaplasma phagocytophilum in Persistently Infected Lambs.Veterinary sciences · 2018Article
- A comparison of nonlinear mixed models and response to selection of tick-infestation on lambs.PloS one · 2017Article
- Antigenic Variation in Bacterial Pathogens.Microbiology spectrum · 2016Article
- Anaplasma marginale and Anaplasma phagocytophilum: Rickettsiales pathogens of veterinary and public health significance.Parasitology research · 2015Review
- Mini-review: Strategies for Variation and Evolution of Bacterial Antigens.Computational and structural biotechnology journal · 2015Review
- Comparative genomics of first available bovine Anaplasma phagocytophilum genome obtained with targeted sequence capture.BMC genomics · 2014Article
- Prevalence and Diversity among Anaplasma phagocytophilum Strains Originating from Ixodes ricinus Ticks from Northwest Norway.Journal of pathogens · 2014Article
- Anaplasma phagocytophilum--a widespread multi-host pathogen with highly adaptive strategies.Frontiers in cellular and infection microbiology · 2013Review
- Antigen variability in Anaplasma phagocytophilum during chronic infection of a reservoir host.Microbiology (Reading, England) · 2012Article
- Adaptive immunity to Anaplasma pathogens and immune dysregulation: implications for bacterial persistence.Comparative immunology, microbiology and infectious diseases · 2012Review
- Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells.Nature reviews. Microbiology · 2010Review
- Variant -and individual dependent nature of persistent Anaplasma phagocytophilum infection.Acta veterinaria Scandinavica · 2010Article
- Prevalence ofJFMS open reportsArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Anaplasma phagocytophilum is the causative agent of tick-borne fever in small ruminants and has been identified as the zoonotic agent of human granulocytic anaplasmosis. The Norwegian strains of the rickettsia are naturally persistent in lambs and represent a suitable experimental system for analyzing the mechanisms of persistence. Variation of the outer membrane protein MSP2(P44) by recombination of variable pseudogene segments into an expression site is believed to play a key role in persistence of the organism. The goal of the present study was to analyze the dynamics of the immune response towards A. phagocytophilum and MSP2(P44) during persistent infection of lambs. Responses to the hypervariable region of MSP2(P44) were detected shortly after appearance of the respective variants in cyclic rickettsemic peaks, consistent with a process of antigenic variation. In addition, there was a diminishing antibody response to MSP2(P44) and to other A. phagocytophilum antigens overall with time of infection, that was not associated with clearance of the infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.