ArticleFEBS letters2009
Unconventional secretion of tubby and tubby-like protein 1.
Article in FEBS letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- TMEM145 is a key stereociliary component in the link structures of outer hair cells and mediates the secretion of stereocilin and tubby.Nature communications · 2025Article
- Retrograde Transport of Tobacco Phytaspase Is Mediated by Its Partner, Tubby-like F-Box Protein 8.International journal of molecular sciences · 2025Article
- The Phagocytic Code Regulating Phagocytosis of Mammalian Cells.Frontiers in immunology · 2021Review
- Distinct roles of stereociliary links in the nonlinear sound processing and noise resistance of cochlear outer hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Through Reducing ROS Production, IL-10 Suppresses Caspase-1-Dependent IL-1β Maturation, thereby Preventing Chronic Neuroinflammation and Neurodegeneration.International journal of molecular sciences · 2020Article
- Non-photoreceptor Expression ofFrontiers in neuroscience · 2020Article
- TYRO3: A potential therapeutic target in cancer.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- The regulatory role of hepatoma-derived growth factor as an angiogenic factor in the eye.Molecular vision · 2016Article
- Synergistic interaction of tubby and tubby-like protein 1 (Tulp1).Advances in experimental medicine and biology · 2014Article
- ALG-2-interacting Tubby-like protein superfamily member PLSCR3 is secreted by an exosomal pathway and taken up by recipient cultured cells.Bioscience reports · 2013Article
- Drosophila king tubby (ktub) mediates light-induced rhodopsin endocytosis and retinal degeneration.Journal of biomedical science · 2012Article
- Eat-me signals: keys to molecular phagocyte biology and "appetite" control.Journal of cellular physiology · 2012Review
- Unraveling the molecular mystery of retinal pigment epithelium phagocytosis.Advances in experimental medicine and biology · 2012Article
- Identification of phosphorylation sites on extracellular corneal epithelial cell maspin.Proteomics · 2011Article
- Autophagy: a broad role in unconventional protein secretion?Trends in cell biology · 2011Article
- Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.The EMBO journal · 2010Article
- Identification of tubby and tubby-like protein 1 as eat-me signals by phage display.Experimental cell research · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Tubby-like proteins (Tulps) with no signal peptide have been characterized as cytoplasmic proteins with various intracellular functions, including binding to phosphatidylinositol-4,5-bisphosphate [PI(4,5)P(2)]. PI(4,5)P(2) has been implicated in unconventional secretion of fibroblast growth factor-2 without a signal peptide. Here, we show that all Tulps are expressed intracellularly and extracellularly. Tubby secretion is partially dependent on its PI(4,5)P(2)-binding activity with an essential secretory signal in the N-terminus. Pathogenic mutation in Tubby mice has no impact on tubby extracellular trafficking. Moreover, unconventional secretion of tubby and Tulp1 is independent of endoplasmic reticulum-Golgi pathway. These data implicate that Tulps may function extracellularly as well.
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Registered trials
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