ArticleGenes, brain, and behavior2009
Clustering by neurocognition for fine mapping of the schizophrenia susceptibility loci on chromosome 6p.
Article in Genes, brain, and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- A systematic review and narrative synthesis of data-driven studies in schizophrenia symptoms and cognitive deficits.Translational psychiatry · 2020Pooled it
- Absence of Thioredoxin Domain Containing 5 Improves Glucose Tolerance and Insulin Sensitivity in Male Mice.International journal of molecular sciences · 2026Article
- Thioredoxin Domain Containing 5 (TXNDC5): Friend or Foe?Current issues in molecular biology · 2024Review
- Linking enlarged choroid plexus with plasma analyte and structural phenotypes in clinical high risk for psychosis: A multisite neuroimaging study.Brain, behavior, and immunity · 2024Article
- The role and mechanism of TXNDC5 in disease progression.Frontiers in immunology · 2024Review
- The role and mechanism of TXNDC5 in diseases.European journal of medical research · 2022Review
- Canonical Correlation Analysis of Imaging Genetics Data Based on Statistical Independence and Structural Sparsity.IEEE journal of biomedical and health informatics · 2020Article
- A critical role of the thioredoxin domain containing protein 5 (TXNDC5) in redox homeostasis and cancer development.Genes & diseases · 2018Review
- Article
- Attempts to replicate genetic associations with schizophrenia in a cohort from north India.NPJ schizophrenia · 2017Article
- Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations.Psychopharmacology · 2015Article
- TXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology.International journal of molecular sciences · 2014Review
- Performance on the Wisconsin Card Sorting Test in families of schizophrenia patients with different familial loadings.Schizophrenia bulletin · 2013Article
- Symptom dimensions as alternative phenotypes to address genetic heterogeneity in schizophrenia and bipolar disorder.European journal of human genetics : EJHG · 2012Article
- Investigating a pathogenic role for TXNDC5 in rheumatoid arthritis.Arthritis research & therapy · 2011Article
- Using an uncertainty-coding matrix in Bayesian regression models for haplotype-specific risk detection in family association studies.PloS one · 2011Article
Corrections and comments
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Authors and funding
21 authors at 11 institutions in 2 countries.
Funding
Abstract
Chromosome 6p is one of the most commonly implicated regions in the genome-wide linkage scans of schizophrenia, whereas further association studies for markers in this region were inconsistent likely due to heterogeneity. This study aimed to identify more homogeneous subgroups of families for fine mapping on regions around markers D6S296 and D6S309 (both in 6p24.3) as well as D6S274 (in 6p22.3) by means of similarity in neurocognitive functioning. A total of 160 families of patients with schizophrenia comprising at least two affected siblings who had data for eight neurocognitive test variables of the continuous performance test (CPT) and the Wisconsin card sorting test (WCST) were subjected to cluster analysis with data visualization using the test scores of both affected siblings. Family clusters derived were then used separately in family-based association tests for 64 single nucleotide polymorphisms (SNPs) covering the region of 6p24.3 and 6p22.3. Three clusters were derived from the family-based clustering, with deficit cluster 1 representing deficit on the CPT, deficit cluster 2 representing deficit on both the CPT and the WCST, and a third cluster of nondeficit. After adjustment using false discovery rate for multiple testing, SNP rs13873 and haplotype rs1225934-rs13873 on BMP6-TXNDC5 genes were significantly associated with schizophrenia for the deficit cluster 1 but not for the deficit cluster 2 or nondeficit cluster. Our results provide further evidence that the BMP6-TXNDC5 locus on 6p24.3 may play a role in the selective impairments on sustained attention of schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.