ArticleCancer science2009
Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages.
Article in Cancer science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Mechanisms of lymphoma-stromal interactions focusing on tumor-associated macrophages, fibroblastic reticular cells, and follicular dendritic cells.Journal of clinical and experimental hematopathology : JCEH · 2024Review
- Overexpression of SerpinB9 in non-seminomatous germ cell tumors.Medical molecular morphology · 2024Article
- Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes.Cancer science · 2023Review
- SRA inhibition improves antitumor potency of antigen-targeted chaperone vaccine.Frontiers in immunology · 2023Article
- Review
- The role of macrophages in anti-tumor immune responses: pathological significance and potential as therapeutic targets.Human cell · 2021Review
- The immunological impact of preoperative chemoradiotherapy on the tumor microenvironment of pancreatic cancer.Cancer science · 2021Article
- Type I IFN, Ly6CMolecular cancer therapeutics · 2020Article
- Article
- Triggering MSR1 promotes JNK-mediated inflammation in IL-4-activated macrophages.The EMBO journal · 2019Article
- Positive correlation between the density of macrophages and T-cells in undifferentiated sarcoma.Medical molecular morphology · 2019Article
- High density of CD204-positive macrophages predicts worse clinical prognosis in patients with breast cancer.Cancer science · 2017Article
- MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis.Oncogene · 2016Article
- Scavenger Receptors: Emerging Roles in Cancer Biology and Immunology.Advances in cancer research · 2015Review
- Fucoidan as a marine anticancer agent in preclinical development.Marine drugs · 2014Review
- Article
- Clinical significance of macrophage heterogeneity in human malignant tumors.Cancer science · 2014Review
- Tumour macrophages as potential targets of bisphosphonates.Journal of translational medicine · 2011Review
- CD204 suppresses large heat shock protein-facilitated priming of tumor antigen gp100-specific T cells and chaperone vaccine activity against mouse melanoma.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation.Cancer science · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Class A scavenger receptors (SR-A, CD204) are highly expressed in tumor-associated macrophages (TAM). To investigate the function of SR-A in TAM, wild-type and SR-A-deficient (SR-A(-/-)) mice were injected with EL4 cells. Although these groups of mice did not differ in the numbers of infiltrating macrophages and lymphocytes and in neovascularization, SR-A(-/-) mice had delayed growth of EL4 tumors. Expression of inducible nitric oxide (NO) synthase and interferon (IFN)-gamma mRNA increased significantly in tumor tissues from SR-A(-/-) mice. Engulfment of necrotic EL4 cells induced upregulation of NO and IFN-gamma production by cultured macrophages, and production of NO and IFN-gamma increased in SR-A(-/-) macrophages in vitro. IFN-beta production by cultured macrophages was also elevated in SR-A(-/-) macrophages in vitro. These results suggested that the antitumor activity of macrophages increased in SR-A(-/-) mice because of upregulation of NO and IFN-gamma production. These data indicate an important role of SR-A in regulating TAM function by inhibiting toll-like receptor (TLR)4-IFN-beta signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.