ArticleImmunogenetics1990
Organization of a functional chicken class II B gene.
Article in Immunogenetics, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 105 citations in OpenAlex.
- Novel MHCArchives animal breeding · 2023Article
- The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek's disease virus peptides by using an unprecedented binding motif.PLoS biology · 2021Article
- Brief review of the chicken Major Histocompatibility Complex: the genes, their distribution on chromosome 16, and their contributions to disease resistance.Poultry science · 2016Review
- Evolution of MHC class I in the order Crocodylia.Immunogenetics · 2014Article
- Article
- MHC class IIB exon 2 polymorphism in the Grey partridge (Perdix perdix) is shaped by selection, recombination and gene conversion.PloS one · 2013Article
- Defining the turkey MHC: identification of expressed class I- and class IIB-like genes independent of the MHC-B.Immunogenetics · 2011Article
- Characterization of the MHC class II α-chain gene in ducks.Immunogenetics · 2011Article
- MHC class I loci of the Bar-Headed goose (Anser indicus).Genetics and molecular biology · 2010Article
- Article
- Patterns of variation of the major histocompatibility complex class IIB loci in Chinese goose (Anser Cygnoides).Immunogenetics · 2009Article
- Structure and evolution of a new avian MHC class II B gene in a sub-Antarctic seabird, the thin-billed prion (Procellariiformes: Pachyptila belcheri).Journal of molecular evolution · 2009Article
- Isolation and characterization of major histocompatibility complex (MHC) class II B genes in the Barn owl (Aves: Tyto alba).Immunogenetics · 2008Article
- Support for the minimal essential MHC hypothesis: a parrot with a single, highly polymorphic MHC class II B gene.Immunogenetics · 2008Article
- Characterization, polymorphism, and evolution of MHC class II B genes in birds of prey.Journal of molecular evolution · 2007Article
- The Mhc class II of the Black grouse (Tetrao tetrix) consists of low numbers of B and Y genes with variable diversity and expression.Immunogenetics · 2007Article
- 2004 Nomenclature for the chicken major histocompatibility (B and Y) complex.Immunogenetics · 2004Review
- A comparison of intraspecific patterns of DNA sequence variation in mitochondrial DNA, alpha-enolase, and MHC class II B loci in auklets (Charadriiformes: Alcidae).Journal of molecular evolution · 2003Article
- The properties of the single chicken MHC classical class II alpha chain ( B-LA) gene indicate an ancient origin for the DR/E-like isotype of class II molecules.Immunogenetics · 2003Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Five class II (B-L) B genes are encoded in the major histocompatibility complex (MHC) of chickens of the B12 haplotype. We report here the nucleotide sequence of one of these genes, B-LBII, as well as the primary structure of a corresponding cDNA. The organization of B-LBII, its 5' flanking region including the promotor region, and the amino acid sequence of its product are compared to mammalian class II B genes and to the previously described B-LBIII gene, which probably is a pseudogene since no B-LBIII transcript could be identified. The 5' flanking region of B-LBII exhibits homologs of transcription-controlling sequence motifs, namely S, X, X2, and Y boxes, of class II A and B genes of rodents and man. However, the promotor region of B-LBIII lacks an equivalent of the S box, displays two nucleic acid substitutions in the core sequence of the Y box, and exhibits a 16 base pair (bp) deletion upstream of the site of initiation of transcription. Therefore, an aberrant promotor region is likely to account for the pseudogene-like nature of B-LBIII, which displays open-reading frames in all exons. The data obtained with the functional B-LBII gene are in line with our previous interpretation that both genomic organization and tertiary structure of class II beta molecules are remarkably conserved between birds and mammals.
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