ArticleMolecular biology reports2010
Identification of a novel human cancer/testis gene MAEL that is regulated by DNA methylation.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Meta-analysis of expression of l(3)mbt tumor-associated germline genes supports the model that a soma-to-germline transition is a hallmark of human cancers.International journal of cancer · 2014Pooled it
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- Maelstrom promotes tumor metastasis through regulation of FGFR4 and epithelial-mesenchymal transition in epithelial ovarian cancer.Journal of ovarian research · 2022Article
- Dietary Conjugated Linoleic Acid Reduces Body Weight and Fat inNutrients · 2022Article
- MAEL as a diagnostic marker for the early detection of esophageal squamous cell carcinoma.Diagnostic pathology · 2021Article
- A Comprehensive Molecular and Clinical Analysis of the piRNA Pathway Genes in Ovarian Cancer.Cancers · 2020Article
- MAEL Cancer-Testis Antigen as a Diagnostic Marker in Primary Stages of Gastric Cancer with Helicobacter pylori Infection.Journal of gastrointestinal cancer · 2020Article
- Article
- Quantitative Proteomic Profiling of the Human Ovary from Early to Mid-Gestation Reveals Protein Expression Dynamics of Oogenesis and Folliculogenesis.Stem cells and development · 2018Article
- Defining Driver DNA Methylation Changes in Human Cancer.International journal of molecular sciences · 2018Review
- Article
- Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives.Scientific reports · 2017Article
- Methylomic changes during conversion to psychosis.Molecular psychiatry · 2017Article
- Mael is essential for cancer cell survival and tumorigenesis through protection of genetic integrity.Oncotarget · 2017Article
- Article
- Putative RNA-directed adaptive mutations in cancer evolution.Transcription · 2016Article
- Serine/threonine kinases 31(STK31) may be a novel cellular target gene for the HPV16 oncogene E7 with potential as a DNA hypomethylation biomarker in cervical cancer.Virology journal · 2016Article
- Article
- Epigenetic regulation of the X-chromosomal macrosatellite repeat encoding for the cancer/testis gene CT47.European journal of human genetics : EJHG · 2012Article
- Methylated promoters of genes encoding protocadherins as a new cancer biomarker family.Molecular biology reports · 2012Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse maelstrom (MAEL) gene has been found to be expressed in male germ cells and to play a role in spermatogenesis. Here, we cloned the human MAEL gene by digital differential display and found that, among human tissues, MAEL is only expressed in the testis, but it is also expressed in various cancer cell lines. The transcription start site of the MAEL gene is 74-bp upstream of the start codon. The region from -216 to +150 is the basal promoter of the MAEL gene, and a CpG island (-295 to +148) is located in this region. Treatment with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated MAEL expression. These results suggest that MAEL is a novel cancer/testis-associated gene and is regulated by DNA methylation.
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