ArticleWorld journal of pediatrics : WJP2009
Melatonin protects against oxidative damage in a neonatal rat model of bronchopulmonary dysplasia.
Article in World journal of pediatrics : WJP, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 47 citations in OpenAlex.
- Prenatal Melatonin Therapy Enhances Postnatal Lung Development in a Mouse Model of Inflammation-Induced Preterm Birth.Antioxidants (Basel, Switzerland) · 2025Article
- Oxidative stress in pediatric diseases associated with the origin of life and growth and development.Frontiers in cell and developmental biology · 2025Review
- Melatonin Activates KEAP1/NRF2/PTGS2 Pathway to Attenuate Hyperoxia-Driven Ferroptosis in Bronchopulmonary Dysplasia.Journal of inflammation research · 2025Article
- The rationale of using angiotensin receptor blocker instead of pulmonary vasodilators to treat pulmonary hypertension in bronchopulmonary dysplasia: a case report and literature review.Frontiers in pediatrics · 2025Article
- Protective Effects of Resveratrol Against Airway Hyperreactivity, Oxidative Stress, and Lung Inflammation in a Rat Pup Model of Bronchopulmonary Dysplasia.Physiological research · 2024Article
- Article
- Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study.Frontiers in pediatrics · 2022Article
- Effects of Antioxidants in Human Milk on Bronchopulmonary Dysplasia Prevention and Treatment: A Review.Frontiers in nutrition · 2022Review
- Supplemental Oxygen in the Newborn: Historical Perspective and Current Trends.Antioxidants (Basel, Switzerland) · 2021Review
- Use of Melatonin in Oxidative Stress Related Neonatal Diseases.Antioxidants (Basel, Switzerland) · 2020Review
- Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment.American journal of respiratory cell and molecular biology · 2015Article
- Role of reactive oxygen species in neonatal pulmonary vascular disease.Antioxidants & redox signaling · 2014Review
- The role of genetic polymorphisms in antioxidant enzymes and potential antioxidant therapies in neonatal lung disease.Antioxidants & redox signaling · 2014Review
- Antioxidant strategies and respiratory disease of the preterm newborn: an update.Oxidative medicine and cellular longevity · 2014Review
- Bench to cribside: the path for developing a neuroprotectant.Translational stroke research · 2013Review
- Protective role of melatonin in neonatal diseases.Oxidative medicine and cellular longevity · 2013Review
- Future applications of antioxidants in premature infants.Current opinion in pediatrics · 2011Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxidative stress plays an important role in the pathogenesis of bronchopulmonary dysplasia (BPD). Melatonin (MT) has direct and indirect free radical detoxifying activity. The present study was to investigate whether treatment with MT would attenuate hyperoxia-induced lung injury and the effect of MT on imbalance of oxidants/antioxidants in the lung of neonatal rats.
methodsBPD was induced by exposure to hyperoxia in neonatal rats (n=90). The rats were divided randomly into three groups (n=30 each): air-exposed control group, hyperoxia-exposed group, and hyperoxia-exposed MT-treated group. Lung specimens were obtained respectively on day 3, day 7, and day 14 after exposure (n=10 each). Activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), and levels of myeloperoxidase (MPO), nitrite/nitrate, and malondialdehyde (MDA) were assayed. Histopathologic changes were observed in the tissues stained with hematoxylin and eosin and Masson's trichrome stain.
resultsIncreased levels of MPO, nitrite/nitrate, and MDA in the hyperoxia-exposed rats were significantly reduced by MT (P<0.05). Activities of GSH-Px, SOD, and CAT which did not change after exposure to hyperoxia were increased by MT (P<0.05). Furthermore, BPD associated histopathological alterations such as reduced total number of alveoli and interstitial fibrosis were obviously abated in the MT-treated group.
conclusionsMT can reverse oxidants/antioxidants imbalance in damaged lung tissue and thus exert a beneficial effect on hyperoxia-induced lung disease in neonatal rats. With regard to humans, there may be a protective effect of MT on BPD.
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