ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Disruption of Th2 immunity results in a gender-specific expansion of IL-13 producing accessory NK cells during helminth infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- NKp46Frontiers in immunology · 2022Article
- Review
- Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages.PLoS pathogens · 2021Article
- Article
- Linking the effects of helminth infection, diet and the gut microbiota with human whole-blood signatures.PLoS pathogens · 2019Article
- Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway.PloS one · 2019Article
- Effect of the in vivo application of granulocyte colony-stimulating factor on NK cells in bone marrow and peripheral blood.Journal of cellular and molecular medicine · 2018Article
- Heterogeneity across the murine small and large intestine.World journal of gastroenterology · 2014Review
- Immunity to gastrointestinal nematodes: mechanisms and myths.Immunological reviews · 2014Review
- Sex-dependent genetic effects on immune responses to a parasitic nematode.BMC genomics · 2014Article
- Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice.World journal of gastroenterology · 2014Article
- Trichuris muris research revisited: a journey through time.Parasitology · 2013Review
- Trichuris muris: a model of gastrointestinal parasite infection.Seminars in immunopathology · 2012Review
- Cell-mediated autophagy promotes cancer cell survival.Cancer research · 2012Article
- Lymphocyte Migration Inhibition Response in Trichuris muris Infected and Vaccinated Mice.Iranian journal of parasitology · 2011Article
- Activation of natural killer cells during microbial infections.Frontiers in immunology · 2011Article
- The role of sex hormones in the development of Th2 immunity in a gender-biased model of Trichuris muris infection.European journal of immunology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Host gender has previously been identified as a determining factor in the resolution of Trichuris muris infection in mice lacking IL-4 (IL-4KO BALB/c). Worm expulsion in these mice is delayed, but occurs in females. In this study we were able to demonstrate delayed expulsion occurs at day 26 post infection and is associated with the production of the key Th2-associated cytokine IL-13 by both CD4(+) T cells and an auxiliary DX5(+) NK cell source, as well as a concurrent reduction in proinflammatory cytokines. NK cell number was comparably increased in both sexes, but NK cells from male mice were found to express higher levels of the chemokine receptor CXCR3. Depletion of CD4(+) T cells completely prevented parasite expulsion, whereas loss of NK cells resulted in a mild, but significant delay. Furthermore, IL-18 is a cytokine with the capacity to enhance both Th1 and Th2 responses found to be dispensable for worm expulsion in female mice but was a key factor for the suppression of the Th2 response in male IL-4KO mice. In contrast neutralization of IFN-gamma resulted in a complete restoration of typical wild-type BALB/c expulsion kinetics. This study sheds further light on the role of accessory NK cells in supplementing the IL-13-driven immune response when normal Th2 immunity is disrupted, and further identifies host gender as a key factor in determining the generation of "NK cell help".
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.