ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Characterization of a nicotine-sensitive neuronal population in rat entorhinal cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Similar nicotinic excitability responses across the developing hippocampal formation are regulated by small-conductance calcium-activated potassium channels.Journal of neurophysiology · 2018Article
- Cholinergic Modulation of Cortical Microcircuits Is Layer-Specific: Evidence from Rodent, Monkey and Human Brain.Frontiers in neural circuits · 2017Review
- Postsynaptic nicotinic acetylcholine receptors facilitate excitation of developing CA1 pyramidal neurons.Journal of neurophysiology · 2016Article
- Layer-specific cholinergic control of human and mouse cortical synaptic plasticity.Nature communications · 2016Article
- Olfactory dysfunction: its early temporal relationship and neural correlates in the pathogenesis of Alzheimer's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
- Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Illuminating the role of cholinergic signaling in circuits of attention and emotionally salient behaviors.Frontiers in synaptic neuroscience · 2014Review
- Possible contributions of a novel form of synaptic plasticity in Aplysia to reward, memory, and their dysfunctions in mammalian brain.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Review
- Cholinergic receptors: functional role of nicotinic ACh receptors in brain circuits and disease.Pflugers Archiv : European journal of physiology · 2013Review
- Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex.Molecular neurodegeneration · 2013Article
- Article
- Layer-specific modulation of the prefrontal cortex by nicotinic acetylcholine receptors.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
- Short- and long-term consequences of nicotine exposure during adolescence for prefrontal cortex neuronal network function.Cold Spring Harbor perspectives in medicine · 2012Review
- Nicotinic ACh receptors in the hippocampus: role in excitability and plasticity.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Review
- OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons.Nature neuroscience · 2012Article
- Cholinergic coordination of presynaptic and postsynaptic activity induces timing-dependent hippocampal synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Nicotinic acetylcholine receptors in rat forebrain that bind ¹⁸F-nifene: relating PET imaging, autoradiography, and behavior.Synapse (New York, N.Y.) · 2012Article
- α4* Nicotinic acetylcholine receptors modulate experience-based cortical depression in the adult mouse somatosensory cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Cholinergic modulation of cognitive processing: insights drawn from computational models.Frontiers in behavioral neuroscience · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The entorhinal cortex (EC) is a part of the hippocampal complex that is essential to learning and memory, and nicotine affects memory by activating nicotinic acetylcholine receptors (nAChRs) in the hippocampal complex. However, it is not clear what types of neurons in the EC are sensitive to nicotine and whether they play a role in nicotine-induced memory functions. Here, we have used voltage-sensitive dye imaging methods to locate the neuronal populations responsive to nicotine in entorhino-hippocampal slices and to clarify which nAChR subtypes are involved. In combination with patch-clamp methods, we found that a concentration of nicotine comparable to exposure during smoking depolarized neurons in layer VI of the EC (ECVI) by acting through the non-alpha7 subtype of nAChRs. Neurons in the subiculum (Sb; close to the deep EC layers) also contain nicotine-sensitive neurons, and it is known that Sb neurons project to the ECVI. When we recorded evoked EPSCs (eEPSCs) from ECVI neurons while stimulating the Sb near the CA1 region, a low dose of nicotine not only enhanced synaptic transmission (by increasing eEPSC amplitude) but also enhanced plasticity by converting tetanus stimulation-induced short-term potentiation to long-term potentiation; nicotine enhanced synaptic transmission and plasticity of ECVI synapses by acting on both the alpha7 and non-alpha7 subtypes of nAChRs. Our data suggest that ECVI neurons are important regulators of hippocampal function and plasticity during smoking.
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